Oncotarget

Research Papers:

miR-486-5p expression pattern in esophageal squamous cell carcinoma, gastric cancer and its prognostic value

Chuanli Ren _, Hui Chen, Chongxu Han, Deyuan Fu, Lin Zhou, Guangfu Jin, Fuan Wang, Daxin Wang, Yong Chen, Li Ma, Xucai Zheng and Dongsheng Han

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Oncotarget. 2016; 7:15840-15853. https://doi.org/10.18632/oncotarget.7417

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Abstract

Chuanli Ren1,4,*, Hui Chen2,*, Chongxu Han1, Deyuan Fu3, Lin Zhou1, Guangfu Jin4, Fuan Wang5, Daxin Wang1, Yong Chen6, Li Ma7, Xucai Zheng8, Dongsheng Han1

1Clinical Medical Testing Laboratory, Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China

2Geriatric Medicine, Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China

3Breast Oncology Surgery, Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China

4Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China

5Departments of Interventional Radiography, Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China

6Departments of Oncology, Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China

7Laboratory of Hematology, Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China

8Department of Head and Neck Surgery, Anhui Cancer Hospital, Hefei, China

*These authors contributed equally to the work

Correspondence to:

Chuanli Ren, e-mail: renchl@163.com

Keywords: digestive system cancers, esophageal squamous cell carcinoma, gastric adenocarcinoma, micro RNA-486-5p, prognosis

Received: October 19, 2015    Accepted: February 02, 2016    Published: February 16, 2016

ABSTRACT

Micro RNA (miR)-486-5p is often aberrantly expressed in human cancers. The aim of this study was to identify the prognostic value of miR-486-5p expression in digestive system cancers. Tissue microarrays were constructed with 680 samples including 185 esophageal squamous cell carcinomas (ESCCs), 90 gastric adenocarcinomas (GCs), and 60 digestive system cancer tissues from 10 ESCC, 10 GC, 10 colon, 10 rectum, 10 liver, 10 pancreatic cancer, and corresponding normal tissues. Twenty normal digestive system mucosa tissues from healthy volunteers were included as normal controls. In GC, miR-486-5p expression was decreased in 62.8% of cases (59/94), increased in 33.0% (31/94), and unchanged in 4.2% (4/94); in ESCC its expression was decreased in 66.2% (129/195), increased in 32.3% (63/195), and unchanged in 1.5% (3/195). Expression of miR-486-5p was decreased in 12, and increased in 8, of 20 cases of colon or rectum cancer; decreased in 6, and increased in 4, of 10 cases of liver cancer; and decreased in 8, and increased in 2, of 10 cases of pancreatic cancer. Multivariate and univariate regression analysis demonstrated that low/unchanged miR-486-5p predicted poor prognosis in ESCC (hazard ratio [HR], 4.32; 95% confidence interval [CI], 2.62–7.14; P < 0.001; HR, 3.88; 95% CI, 2.43–6.22; P < 0.001, respectively) and GC (HR, 2.46; 95% CI, 1.35–4.50; P = 0.003; HR, 2.55; 95% CI, 1.39–4.69; P = 0.002, respectively). MiR-486-5p might therefore be an independent tumor marker for evaluating prognosis in patients with ESCC or GC.


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