Oncotarget

Research Papers:

PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population

Li-Xin Qiu, Lei Cheng, Jing He, Zhi-Rui Zhou, Meng-Yun Wang, Fei Zhou, Wei-Jian Guo, Jin Li, Meng-Hong Sun, Xiao-Yan Zhou, Ya-Nong Wang, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Xiao-Dong Zhu and Qing-Yi Wei _

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Oncotarget. 2016; 7:9420-9428. https://doi.org/10.18632/oncotarget.7137

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Abstract

Li-Xin Qiu1,2,*, Lei Cheng2,*, Jing He3,*, Zhi-Rui Zhou4, Meng-Yun Wang2, Fei Zhou2, Wei-Jian Guo1, Jin Li1, Meng-Hong Sun5, Xiao-Yan Zhou5, Ya-Nong Wang6, Ya-Jun Yang7,8, Jiu-Cun Wang7,8, Li Jin7,8, Xiao-Dong Zhu1 and Qing-Yi Wei2,9

1 Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

2 Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, China

3 Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China

4 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

5 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China

6 Department of Gastric Cancer & Soft Tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

7 Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China

8 Fudan-Taizhou Institute of Health Sciences, Taizhou, China

9 Duke Cancer Institute, Duke University Medical Center, and Department of Medicine, Duke University School of Medicine, Durham, NC, USA

* These authors have contributed equally to this work

Correspondence to:

Xiao-Dong Zhu, email:

Qing-Yi Wei, email:

Keywords: PSCA, polymorphism, gastric cancer, genetic susceptibility

Received: October 09, 2015 Accepted: January 19, 2016 Published: February 02, 2016

Abstract

The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. The associations between the PSCA rs2294008 and rs2976392 single nucleotide polymorphisms (SNPs) and gastric cancer (GCa) susceptibility were still controversial. To derive a more precise estimation of the associations, we conducted a case-control study of 1,124 cases and 1,192 controls in an eastern Chinese population. We found that the rs2294008T variant genotypes were associated with an increased GCa risk in this study population (CT vs CC, OR=1.59, 95% CI=1.33-1.89 and CT+TT vs CC, OR=1.38, 95% CI=1.17-1.62). For SNP rs2976392, the variant A genotypes were also associated with an increased GCa risk (AG vs GG, OR=1.61, 95% CI=1.35-1.91 and AG+AA vs GG, OR=1.47, 95% CI=1.25-1.74). The results were further validated by a meta-analysis. In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population. However, large and well-designed studies are warranted to validate our findings.


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