Oncotarget

Research Papers: Pathology:

Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)

Laura Leone, Salvatore Raffa, Mario Vetrano, Danilo Ranieri, Florence Malisan, Cristina Scrofani, Maria Chiara Vulpiani, Andrea Ferretti, Maria Rosaria Torrisi and Vincenzo Visco _

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Oncotarget. 2016; 7:6410-6423. https://doi.org/10.18632/oncotarget.7064

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Abstract

Laura Leone1, Salvatore Raffa1,4, Mario Vetrano2, Danilo Ranieri1, Florence Malisan3, Cristina Scrofani1, Maria Chiara Vulpiani2, Andrea Ferretti2, Maria Rosaria Torrisi1,4 and Vincenzo Visco1,4

1 Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, “Sapienza” University of Rome, Rome, Italy

2 Department of Orthopedics and Traumatology, Sant’Andrea Hospital, Faculty of Medicine and Psychology, “Sapienza” University of Rome, Rome, Italy

3 Department of Biomedicine and Prevention, Laboratory of Signal Transduction, “Tor Vergata” University of Rome, Rome, Italy

4 Cellular Diagnostics Unit, Sant’Andrea Hospital, Rome, Italy

Correspondence to:

Vincenzo Visco, email:

Keywords: differentiation, tendon, stem cells, healing, ESWT, Pathology Section

Received: August 03, 2015 Accepted: January 13, 2016 Published: January 28, 2016

Abstract

Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative technology for the management of specific tendinopathies. In order to elucidate the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptured Achilles (AT) tendons were established. While hTSPCs from the two groups showed similar proliferation rates and stem cell surface marker profiles, we found that the clonogenic potential was maintained only in cells derived from healthy donors. Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting that the clinical benefits of ESWT may be ascribed to increased efficiency of tendon repair after injury.


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