Clinical Research Papers:

The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial

Yongzhi Yang, Yang Xia, Hongqi Chen, Leiming Hong, Junlan Feng, Jun Yang, Zhe Yang, Chenzhang Shi, Wen Wu, Renyuan Gao, Qing Wei, Huanlong Qin and Yanlei Ma _

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Oncotarget. 2016; 7:8432-8440. https://doi.org/10.18632/oncotarget.7045

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Yongzhi Yang1,*, Yang Xia2,*, Hongqi Chen2, Leiming Hong1, Junlan Feng2, Jun Yang2, Zhe Yang1, Chenzhang Shi1, Wen Wu1, Renyuan Gao1, Qing Wei3, Huanlong Qin1 and Yanlei Ma1

1 Department of GI Surgery, Shanghai Tenth People’s Hospital Affiliated to Tongji University, Shanghai, China

2 Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

3 Department of Pathology, Shanghai Tenth People’s Hospital Affiliated to Tongji University, Shanghai, China

* These authors have contributed equally to this work

Correspondence to:

Huanlong Qin, email:

Yanlei Ma, email:

Qing Wei, email:

Keywords: colorectal cancer, perioperative probiotics treatment, post-operative outcome, randomised clinical trial

Received: August 03, 2015 Accepted: January 13, 2016 Published: January 27, 2016


This study was designed to mainly evaluate the anti-infective effects of perioperative probiotic treatment in patients receiving confined colorectal cancer (CRC) respective surgery. From November 2011 to September 2012, a total of 60 patients diagnosed with CRC were randomly assigned to receive probiotic (n = 30) or placebo (n = 30) treatment. The operative and post-operative clinical results including intestinal cleanliness, days to first - flatus, defecation, fluid diet, solid diet, duration of pyrexia, average heart rate, length of intraperitoneal drainage, length of antibiotic therapy, blood index changes, rate of infectious and non-infectious complications, postoperative hospital stay, and mortality were investigated. The patient demographics were not significantly different (p > 0.05) between the probiotic treated and the placebo groups. The days to first flatus (3.63 versus 3.27, p = 0.0274) and the days to first defecation (4.53 versus 3.87, p = 0.0268) were significantly improved in the probiotic treated patients. The incidence of diarrhea was significantly lower (p = 0.0352) in probiotics group (26.67%, 8/30) compared to the placebo group (53.33%, 16/30). There were no statistical differences (p > 0.05) in other infectious and non-infectious complication rates including wound infection, pneumonia, urinary tract infection, anastomotic leakage, and abdominal distension. In conclusion, for those patients undergoing confined CRC resection, perioperative probiotic administration significantly influenced the recovery of bowel function, and such improvement may be of important clinical significance in reducing the short-term infectious complications such as bacteremia.

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