Oncotarget

Research Papers:

Overexpression of TRIM14 promotes tongue squamous cell carcinoma aggressiveness by activating the NF-κB signaling pathway

Xuan Su, Jianning Wang, Weichao Chen, Zhaoqu Li, Xiaoyan Fu and Ankui Yang _

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2016; 7:9939-9950. https://doi.org/10.18632/oncotarget.6941

Metrics: PDF 3527 views  |   HTML 2681 views  |   ?  


Abstract

Xuan Su1,*, Jianning Wang2,*, Weichao Chen1, Zhaoqu Li1, Xiaoyan Fu1, Ankui Yang1

1Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, 510060, P. R. China

2Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Institute of Stomatological Research, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, 510055, China

*These authors have contributed equally to this work

Correspondence to:

Ankui Yang, e-mail: [email protected]

Keywords: TRIM14, TSCC, aggressiveness, NF-κB pathway

Received: August 08, 2015     Accepted: December 26, 2015     Published: January 18, 2016

ABSTRACT

Tongue squamous cells carcinoma (TSCC) is one of the most lethal malignancies of oral cancers and its prognosis remains dismal due to the paucity of effective therapeutic targets. Herein, we showed that Tripartite motif containing 14(TRIM14) is markedly up-regulated in TSCC cell lines and clinical tissues. Immunohistochemical (IHC) analysis of 116 clinical TSCC specimens revealed that TRIM14 expression was significantly correlated with the TNM classification (T: P = 0.01; N: P < 0.001; M: P < 0.001) in patients with TSCC. Multivariate analysis indicated that TRIM14 expression might be an independent prognostic indicator for the survival of patients with TSCC. Ectopic expression of TRIM14 in TSCC cells promoted proliferation, angiogenesis, and increased resistance to cisplatin-induced apoptosis of TSCC cells in vitro. Furthermore, TRIM14 overexpressing significantly promoted the tumorigenicity of TSCC cells in vivo whereas silencing endogenous TRIM14 caused an opposite outcome. Moreover, we demonstrated that TRIM14 enhanced TSCC aggressiveness by activating NF-κB signaling. Together, our results provide new evidence that TRIM14 overexpression promotes the progression of TSCC and might represent a novel therapeutic target for its treatment.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 6941