Oncotarget

Reviews:

The cytoskeletal arrangements necessary to neurogenesis

Claudia Compagnucci _, Fiorella Piemonte, Antonella Sferra, Emanuela Piermarini and Enrico Bertini

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Oncotarget. 2016; 7:19414-19429. https://doi.org/10.18632/oncotarget.6838

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Abstract

Claudia Compagnucci1, Fiorella Piemonte1, Antonella Sferra1, Emanuela Piermarini1 and Enrico Bertini1

1 Department of Neuroscience, Unit of Neuromuscular and Neurodegenerative Diseases, Children’s Research Hospital Bambino Gesù, Rome, Italy

Correspondence to:

Claudia Compagnucci, email:

Keywords: neurogenesis, cytoskeleton, induced pluripotent stem cells (iPSCs), actin, tubulins

Received: August 11, 2015 Accepted: January 02, 2016 Published: January 07, 2016

Abstract

During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a series of molecular and morphological changes. The understanding of the physio-pathology of mechanisms controlling the molecular and morphological changes occurring during neuronal differentiation is fundamental to the development of effective therapies for many neurologic diseases. Unfortunately, our knowledge of the biological events occurring in the cell during neuronal differentiation is still poor. In this study, we focus preliminarily on the relevance of the cytoskeletal rearrangements, which earlier drive the morphology of the neuronal precursors, and later the migrating/mature neurons. In fact, neuritogenesis, neurite branching, outgrowth and retraction are seminal to the development of a fully functional nervous system. With this in mind, we highlight the importance of iPSC technology to study the processes of cytoskeletal-driven morphological changes during neuronal differentiation.


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