Research Papers: Gerotarget (Focus on Aging):

Association between serum uric acid and bone health in general population: a large and multicentre study

Xianfeng Lin, Chenchen Zhao, An Qin, Dun Hong, Wenyue Liu, Kangmao Huang, Jian Mo, Hejun Yu, Shengjie Wu and Shunwu Fan _

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Oncotarget. 2015; 6:35395-35403. https://doi.org/10.18632/oncotarget.6173

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Xianfeng Lin1,*, Chenchen Zhao1,*, An Qin2,*, Dun Hong3 , Wenyue Liu4, Kangmao Huang1, Jian Mo1, Hejun Yu1, Shengjie Wu5 and Shunwu Fan1

1 Department of Orthopedics Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China

2 Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

3 Department of Orthopedics Surgery, Taizhou Hospital of Wenzhou Medical University, Linhai, China

4 Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

5 Department of Cardiology, The Key Laboratory of Cardiovascular Disease of Wenzhou The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

* These authors have contributed equally to this work

Correspondence to:

Shunwu Fan, email:

Shengjie Wu, email:

Keywords: serum uric acid, bone health, bone mineral density, bone mass loss, DXA, Gerotarget

Received: June 30, 2015 Accepted: October 06, 2015 Published: October 19, 2015


Previous studies proposed that serum uric acid (UA), an endogenous antioxidant, could be a protective factor against bone loss. However, recently, a study with a population of US adults did not note the protective effects of serum UA. Therefore, the exact association between serum UA and bone health remains unclear. We performed a retrospective consecutive cohort study in a Chinese population to examine the association between serum UA and bone health. This cross-sectional study included 17,735 individuals who underwent lumbar spine bone mineral density (BMD) measurements as part of a health examination. In covariance analyses (multivariable-adjusted), a high serum UA level was associated with a high BMD, T-score, and Z-score. In binary logistic regression analyses (multivariable-adjusted), a high serum UA level was associated with low odds ratios (ORs) for at least osteopenia and osteoporosis in male (age ≥50 years) (OR = 0.72–0.60 and OR = 0.49–0.39, respectively) and postmenopausal female participants (OR = 0.61–0.51 and OR = 0.66–0.49, respectively). In conclusion, serum UA is associated with BMD, the T-score, and the Z-score, and has a strong protective effect against at least osteopenia and osteoporosis.

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