Research Perspectives:

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells

Mikhail V. Blagosklonny _

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Oncotarget. 2012; 3:601-607. https://doi.org/10.18632/oncotarget.548

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Mikhail V.Blagosklonny1

1 Department of CellStress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA

Received: June 25, 2012; Accepted: June 30, 2012; Published: July 12, 2012;

Keywords: cancer, DNA damaging drugs, side effects, apoptosis, senescence, drug combinations, cyclotherapy


Mikhail V.Blagosklonny, email:


As published recently in Cancer Cell, p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. I discuss that, while treating tumors lacking wt p53, this phenomenon can be exploited to protect normal cells from chemotherapy because all normal cells have wt p53. Also, several therapeutic paradigms can be reassessed, including the role of cellular senescence in cancer therapy.

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