Oncotarget

Clinical Research Papers:

Comparison of survival and clinicopathologic features in colorectal cancer among African American, Caucasian, and Chinese patients treated in the United States: Results from the surveillance epidemiology and end results (SEER) database

Junzhong Lin, Miaozhen Qiu, Ruihua Xu and Adrian Sandra Dobs _

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Oncotarget. 2015; 6:33935-33943. https://doi.org/10.18632/oncotarget.5223

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Abstract

Junzhong Lin1,*, Miaozhen Qiu2,3,*, Ruihua Xu2,* and Adrian Sandra Dobs4

1 Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

2 Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

3 Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

4 Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins Center to Reduce Cancer Disparities, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

* These authors have contributed equally to this work

Correspondence to:

Adrian Sandra Dobs, email:

Keywords: colorectal cancer, race/ethnicity, SEER, survival analysis

Received: July 11, 2015 Accepted: August 07, 2015 Published: August 24, 2015

Abstract

African American patients of colorectal cancer (CRC) were found to have a worse prognosis than Caucasians, but it has not been fully understood about the survival difference among Chinese and these two races above. In this study, we used the Surveillance, Epidemiology and End Results database to analyze the survival difference among these three race/ethnicities in the United States. Adenocarcinoma patients of colorectal cancer with a race/ethnicity of Caucasian, Chinese and African American were enrolled for study. Patients were excluded if they had more than one primary cancer but the CRC was not the first one, had unknown cause of death or unknown survival months. The 5-year cause specific survival (CSS) was our primary endpoint. Totally, there were 585,670 eligible patients for analysis. Chinese patients had the best and African American patients had the worst 5-year CSS (66.7% vs 55.9%), P < 0.001. The 5-year CSS for Caucasian patients was 62.9%. Race/ethnicity was an independent prognostic factor in the multivariate analysis, P < 0.001. The comparison of clinicopathologic factors among these three race/ethnicities showed that the insurance coverage rate, income, percentage that completing high school and percentage of urban residence was lowest in the African American patients. Chinese patients had the highest percentage of married, while African American patients ranked lowest. More African American patients were diagnosed as stage IV and had high percentage of signet ring cell and mucinous adenocarcinoma. It is likely that biological differences as well as socioeconomic status both contribute to the survival disparity among the different race/ethnicities.


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