MicroRNA expression and its implications for diagnosis and therapy of gallbladder cancer
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Zheng Li1,*, Xin Yu1,*, Jianxiong Shen1, Priscilla T.Y. Law2, Matthew T.V. Chan3 and William K.K. Wu3
1 Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2 Department of Microbiology, The Chinese University of Hong Kong, Hong Kong, China
3 Department of Anaesthesia and Intensive Care and State-Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
* These authors have contributed equally to this work
Jianxiong Shen, email:
Keywords: microRNA, gallbladder cancer, proliferation, apoptosis, metastasis
Received: April 01, 2015 Accepted: May 13, 2015 Published: May 22, 2015
Gallbladder cancer is the most common biliary tract malignancy with poor prognosis. MicroRNAs (miRNAs) are a class of small, endogenous, non-coding RNAs of 19–23 nucleotides in length, which regulate gene expression at post-transcriptional and translational levels. Several studies have demonstrated aberrant expression of miRNAs in gallbladder cancer tissues. Recent evidences also demonstrated that specific miRNAs are functionally involved in gallbladder cancer development through modulating cell proliferation, apoptosis, migration, invasion and metastasis. In this review, we explore the possibilities of using miRNAs as prognostic, diagnostic markers and therapeutic targets in gallbladder cancer.
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