Oncotarget

Research Papers:

Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer

Meichun Hu _, Shihong Peng, Yundong He, Min Qin, Xiaonan Cong, Yajing Xing, Mingyao Liu and Zhengfang Yi

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2015; 6:15348-15361. https://doi.org/10.18632/oncotarget.3610

Metrics: PDF 3569 views  |   HTML 3590 views  |   ?  


Abstract

Meichun Hu1, Shihong Peng1, Yundong He1, Min Qin1, Xiaonan Cong1, Yajing Xing1, Mingyao Liu1,2, Zhengfang Yi1

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China

2Institute of Bioscience and Technology, Texas A&M University Health Science Center, Houston, Texas 77030, USA

Correspondence to:

Zhengfang Yi, e-mail: [email protected]

Keywords: Lycorine, hormone-refractory PCa, STAT3 signaling, tumor growth and metastasis

Received: January 06, 2015     Accepted: March 15, 2015     Published: April 12, 2015

ABSTRACT

Lycorine, a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. However, the anti-prostate cancer (PCa) efficacy of Lycorine remains unrevealed. In this context, we figured out Lycorine’s anti-proliferative and anti-migratory properties for PCa treatment. Lycorine inhibited proliferation of various PCa cell lines, induced cell apoptosis and cell death. Here we showed that Lycorine decreased proliferation, migration, invasion, survival and EMT of prostate cancer cell lines. Subcutaneous and orthotopic xenotransplantations by ectopic implantation of the human hormone-refractory PC-3M-luc cells were used to confirm in vivo anticancer effects of Lycorine. Lycorine inhibited both growth and metastasis in multiple organs (liver, lung, kidney, spleen and bone) in vivo and improved mice survival. Lycorine prevented EGF-induced JAK/STAT signaling. Importantly, anti-cancer effects of Lycorine were dependent on STAT expression. We suggest that Lycorine is a potential therapeutic in prostate cancer.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 3610