Oncotarget

Clinical Research Papers:

The influence of marital status on stage at diagnosis and survival of patients with colorectal cancer

Qingguo Li _, Lu Gan, Lei Liang, Xinxiang Li and Sanjun Cai

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Oncotarget. 2015; 6:7339-7347. https://doi.org/10.18632/oncotarget.3129

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Abstract

Qingguo Li1,3, Lu Gan2,3, Lei Liang1,3, Xinxiang Li1,3, Sanjun Cai1,3

1Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China

2Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China

3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

Correspondence to:

Sanjun Cai, e-mail: caisanjun_sh@163.com

Xinxiang Li, e-mail: lxx1149@163.com

Keywords: Colorectal cancer, marital status, SEER, survival analysis

Received: December 15, 2014     Accepted: January 09, 2015     Published: February 06, 2015

ABSTRACT

Marital status was found to be an independent prognostic factor for survival in various cancer types, but it hasn’t been fully studied in colorectal cancer (CRC). The Surveillance, Epidemiology and End Results database was used to compare survival outcomes with marital status in each stage. In total, 112, 776 eligible patients were identified. Patients in the widowed group were more frequently elderly women, more common of colon cancer, and more stage I/II in tumor stage (P < 0.001), but the surgery rate was comparable to that for the married group (94.72% VS 94.10%). Married CRC patients had better 5year cause-specific survival (CSS) than those unmarried (P < 0.05). Further analysis showed that widowed patients always presented the lowest CSS compared with that of other’ group. Widowed patients had 5% reduction 5-year CSS compared with married patients at stage I (94.8% vs 89.8%, P < 0.001), 9.4% reduction at stage II (85.9% vs 76.5%, P < 0.001), 16.7% reduction at stage III (70.6% vs 53.9%, P < 0.001) and 6.2% reduction at stage IV(14.4% VS 8.2%, P < 0.001). These results showed that unmarried patients were at greater risk of cancer specific mortality. Despite favorable clinicpathological characteristics, widowed patients were at highest risk of death compared with other groups.


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