Research Papers:

Cyclin D1 expression in penile cancer

Wesliany Everton Duarte, Jaqueline Diniz Pinho, Syomara Pereira da Costa Melo, Denner Rodrigo Diniz Duarte, Juliana Martins da Guia Ribeiro do Carmo, André Salim Khayat, José Ribamar Rodrigues Calixto, Marcos Adriano Garcia Campos, Rita da Graça Carvalhal Frazão Correa, Antonio Machado Alencar Júnior, Antônio Augusto Lima Teixeira-Júnior and Gyl Eanes Barros Silva _

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Oncotarget. 2024; 15:302-311. https://doi.org/10.18632/oncotarget.28584

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Wesliany Everton Duarte1,2, Jaqueline Diniz Pinho3,5, Syomara Pereira da Costa Melo1,4, Denner Rodrigo Diniz Duarte2, Juliana Martins da Guia Ribeiro do Carmo2, André Salim Khayat5, José Ribamar Rodrigues Calixto4, Marcos Adriano Garcia Campos6, Rita da Graça Carvalhal Frazão Correa7, Antonio Machado Alencar Júnior8, Antônio Augusto Lima Teixeira-Júnior2,9 and Gyl Eanes Barros Silva1,2,8,10

1 Postgraduate Program in Adult Health, Federal University of Maranhão, Maranhão, Brazil

2 Clinical Research Center, University Hospital of the Federal University of Maranhão, São Luís, Brazil

3 State University of Maranhão, Zé Doca, Brazil

4 University Hospital, Federal University of Maranhão, São Luís, Brazil

5 Oncology Research Center, Federal University of Pará, Belém, Brazil

6 Clinical Hospital of Medical School, São Paulo, State University, Unesp, Botucatu, São Paulo, Brazil

7 Postgraduate Program in Nursing, Federal University of Maranhão, Maranhão, Brazil

8 Postgraduate Program in Health Science, Federal University of Maranhão, Maranhão, Brazil

9 Department of Genetics and Postgraduate Program in Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

10 Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

Correspondence to:

Gyl Eanes Barros Silva, email: [email protected]

Keywords: immunohistochemistry; biomarkers; cyclin D1; penile neoplasms

Received: March 05, 2024     Accepted: April 19, 2024     Published: May 14, 2024

Copyright: © 2024 Duarte et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017. A review of clinical, epidemiological, and histopathological data was performed, Human Papillomavírus (HPV) DNA was detected using polymerase chain reaction (PCR) and cyclin D1 expression analysis was performed using immunohistochemical techniques. The data revealed that the absence of cyclin D1 expression was significantly associated with HPV-positive histological subtypes (p = 0.001), while its expression was associated with high-grade tumors (p = 0.014), histological subtype (p = 0.001), presence of sarcomatoid transformation (p = 0.04), and perineural invasion (p = 0.023). Patients with cyclin D1 expression exhibited lower disease-free survival compared to the cyclin D1-negative group, although the difference was not statistically significant. The results suggest that cyclin D1 may be a potential biomarker for PC, especially for poorer prognosis.

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