Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy

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Oncotarget. 2024; 15:123-123. https://doi.org/10.18632/oncotarget.28560

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Changhwan Yoon1, Kevin K. Chang1, Jun Ho Lee1, William D. Tap2, Charles P. Hart3, M. Celeste Simon4 and Sam S. Yoon1

1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
2Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
3Threshold Pharmaceuticals, South San Francisco, CA, USA
4Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Published: February 08, 2024

Copyright: © 2024 Yoon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This article has been retracted: Oncotarget has completed its investigation of this paper. A concerned reader informed the journal of several instances of image duplication. Namely, there is internal duplication between two images in Figure 3C. In addition, two images in Figure 3C are duplicates of images in Figure 6F from a previously published paper [1]. There is also a second internal duplication of one image in both Figures 4B and 6B. In light of these issues, the journal requested clarification regarding these images from the authors. The provided explanations were deemed unacceptable by the Scientific Integrity Office. Based on these facts, Oncotarget has decided to retract this paper.


1. Yoon C, Lee HJ, Park DJ, Lee YJ, Tap WD, Eisinger-Mathason TS, Hart CP, Choy E, Simon MC, Yoon SS. Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas. Br J Cancer. 2015; 113:46–56. https://doi.org/10.1038/bjc.2015.186. [PubMed]

Original article: Oncotarget. 2016; 7:42844–42858. DOI: https://doi.org/10.18632/oncotarget.10212

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