Research Papers:

Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma

Luke A. Rathbun, Anthony M. Magliocco and Anil K. Bamezai _

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Oncotarget. 2023; 14:426-437. https://doi.org/10.18632/oncotarget.28409

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Luke A. Rathbun1, Anthony M. Magliocco2 and Anil K. Bamezai1

1 Department of Biology, Villanova University, Villanova, PA 19085, USA

2 Protean BioDiagnostics, Orlando, FL 32827, USA

Correspondence to:

Anil K. Bamezai, email: [email protected]

Keywords: LY6 gene family; uterine cancer; tumor-associated antigen; patient survival; biomarker

Received: October 20, 2022     Accepted: April 07, 2023     Published: May 04, 2023

Copyright: © 2023 Rathbun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The human Lymphocyte antigen-6 (LY6) gene family has recently gained interest for its possible role in tumor progression. We have carried out in silico analyses of all known LY6 gene expression and amplification in different cancers using TNMplot and cBioportal. We also have analyzed patient survival by Kaplan-Meier plotter after mining the TCGA database. We report that upregulated expression of many LY6 genes is associated with poor survival in uterine corpus endometrial carcinoma (UCEC) cancer patients. Importantly, the expression of several LY6 genes is elevated in UCEC when compared to the expression in normal uterine tissue. For example, LY6K expression is 8.25× higher in UCEC compared to normal uterine tissue, and this high expression is associated with poor survival with a hazard ratio of 2.42 (p-value = 0.0032). Therefore, some LY6 gene products may serve as tumor-associated antigens in UCEC, biomarkers for UCEC detection, and possibly targets for directing UCEC patient therapy. Further analysis of tumor-specific expression of LY6 gene family members and LY6-triggered signaling pathways is needed to uncover the function of LY6 proteins and their ability to endow tumor survival and poor prognosis in UCEC patients.

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