Research Perspectives:

Adopted neoplastic cells and the consequences of their existence

Yuri Lazebnik _

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Oncotarget. 2023; 14:321-341. https://doi.org/10.18632/oncotarget.28408

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Yuri Lazebnik1

1 Lerna Consulting, New Haven, CT 06511, USA

Correspondence to:

Yuri Lazebnik, email: [email protected]

Keywords: tumor microenvironment; horizontal oncogenesis; intercellular bridges; cell fusion; cell repair

Received: March 31, 2023     Accepted: April 03, 2023     Published: April 14, 2023

Copyright: © 2023 Lazebnik. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


A view that guides the bulk of cancer research and oncology posits that each neoplastic cell in a tumor is a genetic offspring of another neoplastic cell. Yet, analyzing tumors from transplant patients has revealed that some normal migratory cells adopt the phenotype of neoplastic cells without acquiring their genome, thus becoming what I suggest to call adopted neoplastic cells. This commentary reviews the evidence for the existence of adopted neoplastic cells, outlines the consequences of their presence, and discusses what kind of cells can be adopted, how, and why.

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