The chromatographic constitution of andiroba oil and its healing effects, compared to the LLLT outcomes, in oral mucositis induced in golden Syrian hamsters: a new treatment option
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Jessica T. Gomes1, Ana Márcia V. Wanzeler1, Sergio M.A. Júnior1, Rosa Helena F. Chaves Soares2, Carolina P. de Oliveira2, Emanuelle de M. Rodrigues2, Bruno M. Soares3, Diego D.F.A. Alcantara3, Rommel M.R. Burbano3 and Fabrício M. Tuji1
1 Department of Dentistry, Federal University of Pará, Guamá, Belém, Pará 66075-970, Brazil
2 Department of Medicine, University Center of Pará, Souza, Belém, Pará 66613-903, Brazil
3 Department of Genetics, Laboratory of Human Cytogenetics, Federal University of Pará, Guamá, Belém, Pará 66075-970, Brazil
|Diego D.F.A. Alcantara,||email:||[email protected]|
Keywords: phytotherapeutic drugs; medical oncology; stomatitis; wound healing; low-level light therapy
Received: July 08, 2022 Accepted: December 07, 2022 Published: January 12, 2023
The oral mucositis is a mucosal alteration that usually arises from oncological treatments, such as chemotherapy, and it is characterized as an inflammatory process. The aim of this study is to demonstrate the chromatographic constitution of Andiroba oil, comparing and evaluating Andiroba oil and laser scarring efficiency in treatments of oral mucositis in hamsters. These animals were submitted to 5-Fluorouracil. A total of 122 animals were used, randomized and divided into the following groups: (a) positive control; (b) laser associated to andiroba oil; (c) laser; (d) andiroba oil; (e) negative control; (f) cyclophosphamide (genotoxicity control). The induction of oral mucositis occurred by the administration of intraperitoneal Fluorouracila (60 mg/kg) and trauma to the mucosa. The laser protocol was performed once a day and the andiroba oil applied 3 times a day (1,5 ml/day). The mucosae were photographed and removed for clinical and histopathological analysis on day 4, 8, 12 and 15. The analysis was based in OM severity, in specific scoring for the clinical and histopathological aspect. Toxicity was evaluated on day 15 using comet assay and it was performed by variant DNA damage parameters. The data were analysed using analysis of variance (ANOVA) Tukey post-test and Kruskal–Wallis Dunn post-test. The “andiroba oil” and “laser” groups presented better results when compared to the control groups and the treatment associations. The andiroba oil presented the best scarring results, even considering its efficiency proximity to the laser treatment. Andiroba and laser, separately, did not present genotoxicity, however their association evidences damage to DNA.
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