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Meeting Reports:

Seventh BHD international symposium: recent scientific and clinical advancement

Mark R. Woodford, Avgi Andreou, Masaya Baba, Irma van de Beek, Chiara Di Malta, Iris Glykofridis, Hannah Grimes, Elizabeth P. Henske, Othon Iliopoulos, Masatoshi Kurihara, Romain Lazor, W. Marston Linehan, Kenki Matsumoto, Stefan J. Marciniak, Yukiko Namba, Arnim Pause, Neil Rajan, Anindita Ray, Laura S. Schmidt, Wei Shi, Ortrud K. Steinlein, Julia Thierauf, Roberto Zoncu, Anna Webb and Mehdi Mollapour _

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Oncotarget. 2022; 13:173-181. https://doi.org/10.18632/oncotarget.28176

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Abstract

Mark R. Woodford1,2,3, Avgi Andreou4, Masaya Baba5, Irma van de Beek6, Chiara Di Malta7,8, Iris Glykofridis9, Hannah Grimes10, Elizabeth P. Henske11, Othon Iliopoulos12,13, Masatoshi Kurihara14, Romain Lazor15, W. Marston Linehan16, Kenki Matsumoto17, Stefan J. Marciniak10, Yukiko Namba18, Arnim Pause19, Neil Rajan20, Anindita Ray21, Laura S. Schmidt22, Wei Shi23, Ortrud K. Steinlein24, Julia Thierauf25,26, Roberto Zoncu27, Anna Webb28 and Mehdi Mollapour1,2,3

1 Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA

2 Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA

3 Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, USA

4 Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK

5 International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan

6 Department of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

7 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

8 Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy

9 Amsterdam UMC, Location VUmc, Human Genetics Department, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

10 Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK

11 Center for LAM Research and Clinical Care, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

12 Center for Cancer Research, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA

13 Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA

14 Pneumothorax Research Center and Division of Thoracic Surgery, Nissan Tamagawa Hospital, Setagayaku, Tokyo, Japan

15 Respiratory Medicine Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

16 Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

17 Department of Respiratory Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK

18 Division of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

19 Department of Biochemistry, Goodman Cancer Research Institute, McGill University, Montréal, Canada

20 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK

21 Indian Statistical Institute, Kolkata, WB, India

22 Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA

23 The Saban Research Institute, Children's Hospital Los Angeles, The Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

24 Institute of Human Genetics, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany

25 Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

26 Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital and Research Group Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany

27 Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA

28 The BHD Foundation, The Myrovlytis Trust, London, UK

Correspondence to:

Mehdi Mollapour, email: mollapom@upstate.edu

Keywords: Birt-Hogg-Dubé syndrome; folliculin; FLCN; tuberous sclerosis complex; LDHA

Received: December 23, 2021     Accepted: December 25, 2021     Published: January 20, 2022

Copyright: © 2022 Woodford et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ABSTRACT

The 7th Birt-Hogg-Dubé (BHD) International Symposium convened virtually in October 2021. The meeting attracted more than 200 participants internationally and highlighted recent findings in a variety of areas, including genetic insight and molecular understanding of BHD syndrome, structure and function of the tumor suppressor Folliculin (FLCN), therapeutic and clinical advances as well as patients’ experiences living with this malady.


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