Appropriate body mass index cutoffs for type 2 diabetes in Xinjiang population: defining the influence of liver aminotransferase
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Jing-Yuan Xu1,2,*, Long-Bao Yang1,*, Zhi-Yi Han3, Kai Wang2, Zhen-Hua Yin2, Ting Wu4, Yong Shao4 and Xiao-Lan Lu1,2
1 Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
2 Department of Gastroenterology, Shanghai Pudong Hospital of Fudan University, Shanghai 201399, China
3 Karamay Central Hospital of Xinjiang, Karamay 834099, China
4 Community Health Service Center of Jinxi Town, Kunshan 215300, China
* These authors contributed equally to this work
Keywords: type 2 diabetes; alanine aminotransferase; aspartate aminotransferase; body mass index
Received: January 01, 2021 Accepted: June 11, 2021 Published: July 06, 2021
Background/Purpose: Recent study suggested that type 2 diabetes (T2DM) attributed to body mass index (BMI) could be influenced by liver aminotransferase. We aim to ascertain the cut-off point of BMI associated with T2DM and the influence of both elevated aminotransferase (AST) and alanine aminotransferase (ALT).
Materials and Methods: In our retrospective cohort study, T2DM was diagnosed when FBS ≥ 7.0 mmol/L, BMI of participants with baseline fasting (FBS) < 7.0 mmol/L was divided by percentiles and by aminotransferanse (ALT and AST ≥ 20 U/L, ALT or AST < 20 U/L). Hazard ratios and the turning point of BMI of high T2DM risk was estimated in totality and different aminotransferanse groups.
Results: During an average follow-up time of 3.71 years of 33346 participants, 1486 developed T2DM, and the average baseline BMI of participants who developed T2DM was 26.22 kg/m2. Cumulative incidence of T2DM was more than 5% when ALT and AST ≥ 20U/L, age over 44, male sex or BMI over 25.39 kg/m2; The risk of T2DM incidence increased as the BMI grow. The turning point of BMI at high risk of T2DM was 25.0 kg/m2 in totality, 25.1 kg/m2 when ALT or AST < 20 U/L and 26.1 kg/m2 when ALT and AST ≥ 20U/L.
Conclusions: BMI of 25.0 kg/m2 was the cutoff point for T2DM development, and there is greater association between BMI and T2DM when ALT or AST < 20 U/L.
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