Oncotarget

Research Papers:

Serum MACC-1: a new biomarker for breast cancer

Meraj Ahmed _ and Mohammad Aslam

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Oncotarget. 2020; 11:4521-4526. https://doi.org/10.18632/oncotarget.27813

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Abstract

Meraj Ahmed1 and Mohammad Aslam1

1 Department of Surgery, JN Medical College, Aligarh Muslim University, Aligarh, UP, India

Correspondence to:

Meraj Ahmed,email: merajdoc@gmail.com

Keywords: serum MACC-1; MACC-1; new biomarker; breast cancer

Received: June 09, 2020     Accepted: October 29, 2020     Published: December 01, 2020

Copyright: © 2020 Ahmed and Aslam. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ABSTRACT

Metastasis-associated in colon cancer-1 (MACC-1) is a newly identified tumor marker, found to express in various normal and cancerous tissue. This study is conducted to evaluate the serum MACC-1 level as a diagnostic marker for breast cancer (BC). Sixty new BC patients were included in this study. Patients who received neoadjuvant chemotherapy or with metastatic disease were excluded. Eighty patients of benign disease were taken as control group. All the patients were females with the mean age of 46.7 ± 10.6 years in study group and 40.2 ± 8.4 years in control group (p = 0.0001). The mean serum MACC-1 level in BC patients was 3.46 ± 1.3 ng/ml which was significantly higher than control mean serum MACC-1 level (1.90 ± 0.2 ng/ml) (p < 0.0001). On ROC analysis, the AUC was 0.98 (p ≤ 0.0001; 95% CI = 0.97–1.0) i.e., a good predictor for breast cancer. At the cut-off value of 2.12 ng/ml, the sensitivity and the specificity of serum MACC-1 were 96.7% and 92.5%, respectively. This study showed that serum MACC-1 can be a potential biomarker for diagnosis and tumor progression in patients with breast cancer.


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