Oncotarget

Research Papers:

Survival after resection of brain metastases with white light microscopy versus fluorescence-guidance: A matched cohort analysis of the Metastasys study data

Abdelhalim Hussein, Veit Rohde, Christina Wolfert, Silvia Hernandez-Duran, Ingo Fiss, Annalen Bleckmann, Alonso Barrantes Freer, Dorothee Mielke and Bawarjan Schatlo _

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Oncotarget. 2020; 11:3026-3034. https://doi.org/10.18632/oncotarget.27688

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Abstract

Abdelhalim Hussein1, Veit Rohde1, Christina Wolfert1, Silvia Hernandez-Duran1, Ingo Fiss1, Annalen Bleckmann2,5, Alonso Barrantes Freer3,4, Dorothee Mielke1,* and Bawarjan Schatlo1,*

1 Department of Neurosurgery, University of Medicine Goettingen, Goettingen, Germany

2 Department of Hematology-Oncology, University of Medicine Goettingen, Goettingen, Germany

3 Institute of Neuropathology, University of Medicine Goettingen, Goettingen, Germany

4 Department of Neuropathology, University Medical Center Leipzig, Leipzig, Germany

5 Department of Medicine A, University Hospital Muenster, Muenster, Germany

* These authors share senior authorship equally

Correspondence to:

Bawarjan Schatlo,email: bawarjan.schatlo@med.uni-goettingen.de

Keywords: brain tumor; brain metastasis; fluorescence-guided surgery; 5-ALA

Received: March 09, 2020     Accepted: June 15, 2020     Published: August 11, 2020

ABSTRACT

Background: Metastatic brain disease continues to have a dismal prognosis. Previous studies achieved a reduction of local recurrence rates by aggressively resecting the peritumoral zone (supramarginal resection) or using 5-aminolaevulinic acid (5-ALA) fluorescence. The aim of the present study is to assess whether the use of 5-ALA has an impact on local recurrence or survival compared to conventional white light microscopic tumor resection.

Materials and Methods: We included consecutive patients who underwent surgical resection of brain metastases. Two groups were compared: In the “white light” group, resection was performed with conventional microscopy. In the 5-ALA group, fluorescence guided peritumoral resection was additionally performed after standard microscopic resection. In-brain recurrence and mortality were compared between groups.

Results: N = 175 patients were included in the study. All baseline parameters were similarly distributed with no significant difference between surgical groups. Local in-brain recurrence occurred in 21/175 patients (12%) with a rate of 15/119 (12.6%) in the white light and 6/56 (10.7%) in the 5-ALA group (p = 0.720). The use of 5-ALA influenced neither in-brain recurrence (OR 0.59 [CI = 95% 0.18; 1.99], p = 0.40) nor mortality (OR 0.71 [CI = 95% 0.27; 1.85], p = 0.49).

Conclusions: The use of 5-ALA did not result in lower in-brain recurrence or mortality compared to the use of white light microscopy. The most prominent predictors of survival remain favorable preoperative performance status, a low tumor diameter and the absence of multiple cerebral lesions.


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