Oncotarget

Research Papers:

Geriatric nutritional risk index as a prognostic marker of pTNM-stage I and II esophageal squamous cell carcinoma after curative resection

Noriyuki Hirahara _, Takeshi Matsubara, Yusuke Fujii, Shunsuke Kaji, Ryoji Hyakudomi, Tetsu Yamamoto, Yuki Uchida, Yoshiko Miyazaki, Kazunari Ishitobi, Yasunari Kawabata and Yoshitsugu Tajima

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Oncotarget. 2020; 11:2834-2846. https://doi.org/10.18632/oncotarget.27670

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Abstract

Noriyuki Hirahara1, Takeshi Matsubara1, Yusuke Fujii1, Shunsuke Kaji1, Ryoji Hyakudomi1, Tetsu Yamamoto1, Yuki Uchida1, Yoshiko Miyazaki1, Kazunari Ishitobi1, Yasunari Kawabata1 and Yoshitsugu Tajima1

1 Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan

Correspondence to:

Noriyuki Hirahara,email: [email protected]

Keywords: geriatric nutritional risk index; esophageal squamous cell carcinoma; curative esophagectomy; cancer-specific survival; pathological tumor-node-metastasis

Received: May 09, 2020     Accepted: June 20, 2020     Published: July 21, 2020

ABSTRACT

The geriatric nutritional risk index (GNRI) is associated with mortality in several malignancies. We retrospectively analyzed whether the GNRI can predict long-term outcomes in 191 patients with esophageal squamous cell carcinoma (ESCC) after curative esophagectomies by evaluating their cancer-specific survival (CSS). In multivariate analyses, serum albumin (hazard ratio [HR], 2.498; p = 0.0043), GNRI (HR, 1.941; p = 0.0181), pathological tumor-node-metastasis (pTNM) stage (HR, 3.884; p < 0.0001), and tumor differentiation (HR, 2.307; p = 0.0066) were independent prognostic factors for CSS.

In pTNM stage I, multivariate analysis identified C-reactive protein (HR, 7.172; p = 0.0483) and GNRI (HR, 5.579; p = 0.0291) as independent prognostic factors for CSS. In univariate analyses in pTNM stages II and III, only low GNRI (p = 0.0095) and low serum albumin levels (p = 0.0119), respectively, were significantly associated with worse CSS. In patients with low GNRI, CSS was significantly worse than in those with normal GNRI (p = 0.0011), especially in pTNM stages I (p = 0.0044) and II (p = 0.0036) groups, but not in stage III group (p = 0.5099).

Preoperative GNRI may sort patients into low- or high-risk groups for shorter CSS, especially in those with pTNM stage I and II ESCC.


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