Oncotarget

Research Papers:

Preoperative geriatric nutritional risk index is a useful prognostic indicator in elderly patients with gastric cancer

Noriyuki Hirahara _, Takeshi Matsubara, Yusuke Fujii, Shunsuke Kaji, Ryoji Hyakudomi, Tetsu Yamamoto, Yuki Uchida, Yoshiko Miyazaki, Kazunari Ishitobi, Yasunari Kawabata and Yoshitsugu Tajima

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Oncotarget. 2020; 11:2345-2356. https://doi.org/10.18632/oncotarget.27635

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Abstract

Noriyuki Hirahara1, Takeshi Matsubara1, Yusuke Fujii1, Shunsuke Kaji1, Ryoji Hyakudomi1, Tetsu Yamamoto1, Yuki Uchida1, Yoshiko Miyazaki1, Kazunari Ishitobi1, Yasunari Kawabata1 and Yoshitsugu Tajima1

1 Department of Digestive and General Surgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan

Correspondence to:

Noriyuki Hirahara,email: norinorihirahara@yahoo.co.jp

Keywords: geriatric nutritional risk index; overall survival; cancer-specific survival; gastric cancer; elderly patients

Received: April 20, 2020     Accepted: May 25, 2020     Published: June 16, 2020

ABSTRACT

Background: The geriatric nutritional risk index (GNRI) was developed to evaluate the prognosis in elderly hospitalized patients at risk of malnutrition and related morbidity and mortality. This study aimed to evaluate the relationship between preoperative GNRI and long-term outcomes in elderly gastric cancer patients.

Materials and Methods: We retrospectively reviewed 297 consecutive patients aged ≥ 65 years who underwent laparoscopic gastrectomy with R0 resection and evaluated their overall survival (OS) and cancer-specific survival (CSS).

Results: In the univariate analyses, OS was significantly associated with the American Society of Anesthesiologists Physical Status (ASA-PS), tumor size, tumor differentiation, pathological stage, carcinoembryonic antigen (CEA), C-reactive protein, postoperative complications, and GNRI, whereas in the univariate analyses of CSS, ASA-PS, tumor size, tumor differentiation, pathological stage, CEA, postoperative adjuvant chemotherapy, and GNRI were significantly associated with poor prognosis. In the multivariate analysis, ASA-PS, tumor differentiation, pathological stage, and GNRI were significant independent prognostic factors of OS, whereas ASA-PS, pathological stage, and CEA were significant independent prognostic factors of CSS.

Conclusions: GNRI is significantly associated with OS and CSS in elderly gastric cancer patients and is an independent predictor of OS. It is a simple, cost-effective, and promising nutritional index for predicting OS in elderly patients.


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