Correction: Overexpression of CTEN relates to tumor malignant potential and poor outcomes of adenocarcinoma of the esophagogastric junction
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1 Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachihirokoji, Kamigyo-ku, Kyoto, Japan
2 Department of Pathology, National Cancer Center Hospital, Tokyo, Japan
3 Department of Basic Pathology, National Defense Medical College, Saitama, Japan
* These authors contributed equally to this work
Published: October 01, 2019
This article has been corrected: A line in the Abstract section has been corrected to read, “CTEN overexpression was detected in GC cell lines (2/5 cell lines; 40%) and primary AEG tumor samples (69/104 cases; 66%).” The data in the main document and Table 1, Figure 2A remains correct. The authors declare that these corrections do not change the results or conclusions of this paper.
Background: To detect a novel treatment target for adenocarcinoma of the esophagogastric junction (AEG), we tested whether C-terminal tensin-like (CTEN), a member of the tensin gene family and frequently overexpressed in various cancers, acts as a cancer-promoting gene through overexpression in AEG.
Materials and Methods: We analyzed 5 gastric adenocarcinoma (GC) cell lines and 104 primary AEG tumors curatively resected in our hospital between 2000 and 2010.
Results: CTEN overexpression was detected in GC cell lines (2/5 cell lines; 40%) and primary AEG tumor samples (69/104 cases; 66%). CTEN knockdown using several specific siRNAs inhibited the proliferation, migration, and invasion of CTEN-overexpressing cells. CTEN overexpression was significantly correlated with more aggressive venous and lymphatic invasion, deeper tumor depth, and higher rates of lymph node metastasis and recurrence. Patients with CTEN-overexpressing tumors had a worse overall rate of survival than those with non-expressing tumors (P < 0.0001, log-rank test) in an expression-dependent manner. CTEN positivity was independently associated with a worse outcome in the multivariate analysis (P = 0.0423, hazard ratio 3.54 [1.04–16.4]).
Conclusions: CTEN plays a crucial role in tumor cell proliferation, migration, and invasion through its overexpression, which highlights its usefulness as a prognosticator and potential therapeutic target in AEG.
Original article: Oncotarget. 2017; 8:84112–84122. DOI: https://doi.org/10.18632/oncotarget.21109.
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