New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses
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Aysha AlSahlawi1,2,3,*, Rasha Aljelaify1,4,*, Amna Magrashi5, Mariam AlSaeed1,4, Amal Almutairi1,4, Fatimah Alqubaishi1,4, Abdulellah Alturkistani3, Abdullah AlObaid3, Mohamed Abouelhoda4,5, Latifa AlMubarak1,4, Nada AlTassan4,5 and Malak Abedalthagafi1,5,*
1 Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City and King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia
2 Montreal Neurological Institute, Montreal, Canada
3 Neurosurgery Department, King Fahad Medical City, Riyadh, Saudi Arabia
4 Saudi Human Genome Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia
5 Genetics Department, King Faisal Specialists Hospital and Research Center, Riyadh, Saudi Arabia
* These authors contributed equally to this work
Keywords: meningioma; FGFR3; NGS; genomics; CNS
Received: May 31, 2019 Accepted: August 12, 2019 Published: September 17, 2019
This study aimed to further investigate the association of mutational profiles with anatomical distribution, histological subtype, WHO grade, and recurrence in patients with meningioma.
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