Case Reports:

Histological transformation in duodenal-type follicular lymphoma: a case report and review of the literature

Tomohiko Tanigawa, Ryohei Abe, Jun Kato, Naoki Hosoe, Haruhiko Ogata, Kaori Kameyama, Shinichiro Okamoto and Takehiko Mori

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Oncotarget. 2019; 10:3424-3429. https://doi.org/10.18632/oncotarget.26912

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Tomohiko Tanigawa1, Ryohei Abe1, Jun Kato1, Naoki Hosoe2, Haruhiko Ogata2, Kaori Kameyama3, Shinichiro Okamoto1 and Takehiko Mori1

1 Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan

2 Center for Diagnostic and Therapeutic Endoscopy, Keio University Hospital, Tokyo, Japan

3 Department of Diagnostic Pathology, Keio University Hospital, Tokyo, Japan

Correspondence to:

Takehiko Mori,email: [email protected]

Keywords: duodenal-type follicular lymphoma; histological transformation; duodenum; chemotherapy; prognosis

Received: February 13, 2019     Accepted: April 14, 2019     Published: May 21, 2019


Duodenal-type follicular lymphoma (DFL) is a rare variant of follicular lymphoma (FL) characterized by distinctive clinical features such as localization and favorable prognosis. We herein report a case of DFL in which histological transformation into diffuse large B-cell lymphoma developed 7 years after diagnosis. The transformed lymphoma was refractory to chemotherapy, and the patient passed away due to disease progression. To date, there have been only a limited number of reported cases of histological transformation of DFL, and the clinical outcomes of those cases except our present case have been favorable, with good responses to chemotherapy. Although the histological transformation of DFL is a rare event, the clinical course of the present case suggested that it would be a fatal event and underscore the importance of the life-long management of DFL. Further accumulation of cases is required to elucidate its incidence, characteristics, and prognosis.

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