Research Papers:
Leptin receptor polymorphisms are associated with risk of essential hypertension in the Mongolian and Han populations of China
Menglu Yuan1, Lifu Bi1 and Xiulan Su1
1Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China
Correspondence to:
Xiulan Su, email: [email protected]
Keywords: leptin receptor; gene polymorphism; essential hypertension
Received: June 27, 2017 Accepted: November 14, 2017 Published:
ABSTRACT
In this case-control study, we investigated the association between leptin receptor (LEPR) single nucleotide polymorphisms (SNP) and essential hypertension (EH) in the Mongolian and Han ethnic groups from China. We identified 14 LEPR SNPs in the Chinese HapMap database. Genotyping analysis showed that the 14 LEPR SNPs were not associated with EH in the Han study subjects, though the LEPR rs1137100 GG genotype was associated with systolic blood pressure (P < 0.05). In Mongolian subjects, rs1137100 GG, rs1805096 CT, rs1137101 AG, and rs1805134 CT were all associated with protection against EH, whereas rs12037879 AA and rs12037879 AG were associated with EH risk (all P < 0.05). The rs1137100 (AA vs. AG+GG; P = 0.02) and rs1805134 (CC vs. CT+TT; P = 0.02) polymorphisms were associated with diastolic blood pressure in the Mongolians according to the dominant genetic model. Linkage disequilibrium analysis revealed that the GT haplotypes of rs1892535 and rs1805096 were associated with EH risk in the Mongolian population. This study shows that multiple LEPR SNPs are associated with EH risk in the Chinese Mongolian population of China. This suggests leptin/LEPR signaling is a potential target for EH treatment.