Oncotarget

Research Papers:

PARP1-Erk synergism in proliferating cells

Leonid Visochek and Malka Cohen-Armon _

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Oncotarget. 2018; 9:29140-29145. https://doi.org/10.18632/oncotarget.25633

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Abstract

Leonid Visochek1 and Malka Cohen-Armon1,2

1Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel

2Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv 69978, Israel

Correspondence to:

Malka Cohen-Armon, email: marmon@post.tau.ac.il

Keywords: PARP1-Erk binding; PARP1-dependent Erk activity; c-Fos; Mouse embryonic fibroblasts

Received: May 27, 2018     Accepted: May 31, 2018     Published: June 26, 2018

ABSTRACT

A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition during learning. It was similarly required for cardiomyocytes development. Here, we identified this mechanism in Erk-induced gene expression promoting proliferation. This mechanism can be targeted in malignant cells.


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PII: 25633