Oncotarget

Research Papers:

Preoperative tumor size is associated with deep myometrial invasion and lymph node metastases and is a negative prognostic indicator for patients with endometrial carcinoma

Kohei Nakamura _, Kentaro Nakayama, Noriyoshi Ishikawa, Toshiko Minamoto, Tomoka Ishibashi, Kaori Ohnishi, Hitomi Yamashita, Ruriko Ono, Hiroki Sasamori, Sultana Razia, Mohammad Mahmud Hossain, Shanta Kamrunnahar, Masako Ishikawa and Satoru Kyo

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Oncotarget. 2018; 9:23164-23172. https://doi.org/10.18632/oncotarget.25248

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Abstract

Kohei Nakamura1, Kentaro Nakayama1, Noriyoshi Ishikawa2, Toshiko Minamoto1, Tomoka Ishibashi1, Kaori Ohnishi1, Hitomi Yamashita1, Ruriko Ono1, Hiroki Sasamori1, Sultana Razia1, Mohammad Mahmud Hossain1, Shanta Kamrunnahar1, Masako Ishikawa1 and Satoru Kyo1

1Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan

2Department of Organ Pathology, Shimane University School of Medicine, Izumo 6938501, Japan

Correspondence to:

Kentaro Nakayama, email: [email protected]

Keywords: endometrial carcinoma; tumor size; overall survival; progression-free survival; myometrial invasion

Received: January 31, 2018     Accepted: April 07, 2018     Published: May 01, 2018

ABSTRACT

We examined the usefulness of evaluating tumor size determined using preoperative magnetic resonance imaging (MRI) for prognosis in patients with endometrial carcinoma (EC). Patients (N = 184) with EC who underwent surgery at Shimane University Hospital between 1997 and 2013 were enrolled. We investigated the association between the tumor size of EC assessed prior to surgery by MRI (anteroposterior [AP], transverse [TV], and craniocaudal [CC] diameters) and various clinical parameters including deep myometrial invasion and lymph node metastases. We subsequently examined the prognostic significance of tumor size in patients with EC. Survival analysis was performed using the Kaplan-Meier method, and prognostic factors were evaluated using the Cox’s proportional hazards regression model.

Multivariate analysis identified increased AP diameter as an independent negative prognostic factor for overall survival (OS) (P = 0.037). A long AP diameter has prognostic value and the potential to be a predictive marker for surgical outcomes in patients with EC. Furthermore, AP diameter exhibited the greatest area under the curve (AUC) (0.727) for deep myometrial invasion, and CC diameter had the greatest AUC for lymph node metastases (0.854). Evaluation of tumor size parameters may aid in the identification of high-risk populations, which could improve treatment selection and patient outcomes.


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