Research Papers:

High incidence of other primary malignancies in patients with synchronous multiple gastric cancers “a multi-center retrospective cohort study”

Daisuke Takeuchi _, Naohiko Koide, Akira Suzuki, Fumiaki Shimizu, Yoshinori Koyama, Takehito Ehara, Yuta Yamamoto, Makoto Koyama, Satoshi Nakamura, Masato Kitazawa, Yusuke Miyagawa and Shinichi Miyagawa

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Oncotarget. 2018; 9:20605-20616. https://doi.org/10.18632/oncotarget.25027

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Daisuke Takeuchi1, Naohiko Koide2, Akira Suzuki1, Fumiaki Shimizu3, Yoshinori Koyama2, Takehito Ehara1, Yuta Yamamoto1, Makoto Koyama1, Satoshi Nakamura1, Masato Kitazawa1, Yusuke Miyagawa1 and Shinichi Miyagawa1

1Department of Surgery, Shinshu University School of Medicine, Asahi, Matsumoto 390-8621, Japan

2Department of Surgery, Nagano Prefectural Kiso Hospital, Asahi, Matsumoto 390-8621, Japan

3Department of Surgery, Shinshu Ueda Medical Center, Asahi, Matsumoto 390-8621, Japan

Correspondence to:

Daisuke Takeuchi, email: [email protected]

Keywords: multiple gastric cancers; multiple primary cancers; other primary malignancy; gastrectomy; gastric cancer

Received: March 20, 2017     Accepted: March 19, 2018     Published: April 17, 2018


This study evaluated the relationship between synchronous multiple gastric cancer and other primary malignancies. During 2002–2013, 1094 consecutive surgically treated gastric cancer patients were enrolled. Preoperatively, we performed total colonoscopy and whole-body computed tomography. When malignancies in other organs were suspected, detailed organ-specific examinations were performed. Synchronous multiple gastric cancer occurred in 102 patients (9.3%)which was frequently observed in patients with preoperative other primary malignancies (p < 0.001). Preoperative other primary malignancy was an independent risk factor for synchronous multiple gastric cancer (p = 0.001; hazard ratio: 2.145, 95% confidence interval: 1.354–3.399) and an independent prognostic factor of overall survival in patients undergoing gastrectomy with curative intent (p = 0.021; hazard ratio: 1.481, 95% confidence interval: 1.060–2.070). Thus, patients with preoperative other primary malignancies have a high risk of synchronous multiple gastric cancer. Careful preoperative examination is recommended to improve survival.

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