Prostaglandins in the pathogenesis of kidney diseases
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Yuanyuan Li1,2,3,*, Weiwei Xia1,2,3,*, Fei Zhao1,2,3, Zhaoying Wen3, Aihua Zhang1,2,3, Songming Huang1,2,3, Zhanjun Jia1,2,3 and Yue Zhang1,2,3
1Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China
2Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing 210029, China
3Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China
*These authors have contributed equally to this work
Zhanjun Jia, email: [email protected]
Yue Zhang, email: [email protected]
Keywords: prostaglandins; kidney; acute kidney injury; chronic kidney injury
Received: October 17, 2017 Accepted: March 14, 2018 Published: May 29, 2018
Prostaglandins (PGs) are important lipid mediators produced from arachidonic acid via the sequential catalyzation of cyclooxygenases (COXs) and specific prostaglandin synthases. There are five subtypes of PGs, namely PGE2, PGI2, PGD2, PGF2α, and thromboxane A2 (TXA2). PGs exert distinct roles by combining to a diverse family of membrane-spanning G protein-coupled prostanoid receptors. The distribution of these PGs, their specific synthases and receptors vary a lot in the kidney. This review summarized the recent findings of PGs together with the COXs and their specific synthases and receptors in regulating renal function and highlighted the insights into their roles in the pathogenesis of various kidney diseases.
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