Prostaglandins in the pathogenesis of kidney diseases

Yuanyuan Li, Weiwei Xia, Fei Zhao, Zhaoying Wen, Aihua Zhang, Songming Huang, Zhanjun Jia _ and Yue Zhang

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Oncotarget. 2018; 9:26586-26602. https://doi.org/10.18632/oncotarget.25005

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Yuanyuan Li1,2,3,*, Weiwei Xia1,2,3,*, Fei Zhao1,2,3, Zhaoying Wen3, Aihua Zhang1,2,3, Songming Huang1,2,3, Zhanjun Jia1,2,3 and Yue Zhang1,2,3

1Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China

2Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing 210029, China

3Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China

*These authors have contributed equally to this work

Correspondence to:

Zhanjun Jia, email: [email protected]

Yue Zhang, email: [email protected]

Keywords: prostaglandins; kidney; acute kidney injury; chronic kidney injury

Received: October 17, 2017     Accepted: March 14, 2018     Published: May 29, 2018


Prostaglandins (PGs) are important lipid mediators produced from arachidonic acid via the sequential catalyzation of cyclooxygenases (COXs) and specific prostaglandin synthases. There are five subtypes of PGs, namely PGE2, PGI2, PGD2, PGF2α, and thromboxane A2 (TXA2). PGs exert distinct roles by combining to a diverse family of membrane-spanning G protein-coupled prostanoid receptors. The distribution of these PGs, their specific synthases and receptors vary a lot in the kidney. This review summarized the recent findings of PGs together with the COXs and their specific synthases and receptors in regulating renal function and highlighted the insights into their roles in the pathogenesis of various kidney diseases.

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