DWI - histology: a possible means of determining degree of liver fibrosis?

Niklas Verloh; Kirsten Utpatel; Michael Haimerl; Florian Zeman; Claudia Fellner; Marc Dahlke; Philipp Renner; Timo Seyfried; Martina Müller; Christian Stroszczynski; Matthias Evert; Philipp Wiggermann

doi:10.18632/oncotarget.24981

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Clinical Research Papers:

DWI - histology: a possible means of determining degree of liver fibrosis?

Niklas Verloh _, Kirsten Utpatel, Michael Haimerl, Florian Zeman, Claudia Fellner, Marc Dahlke, Philipp Renner, Timo Seyfried, Martina Müller, Christian Stroszczynski, Matthias Evert and Philipp Wiggermann

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Oncotarget. 2018; 9:20112-20118. https://doi.org/10.18632/oncotarget.24981

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Abstract

Niklas Verloh1, Kirsten Utpatel2, Michael Haimerl1, Florian Zeman3, Claudia Fellner1, Marc Dahlke4, Philipp Renner4, Timo Seyfried5, Martina Müller6, Christian Stroszczynski1, Matthias Evert2 and Philipp Wiggermann1

1Department of Radiology, University Hospital Regensburg, Regensburg, Germany

2Department of Pathology, University Regensburg, Regensburg, Germany

3Center for Clinical Trials, University Hospital Regensburg, Regensburg, Germany

4Department of Surgery, University Hospital Regensburg, Regensburg, Germany

5Department of Anaesthesia, University Hospital Regensburg, Regensburg, Germany

6Department of Gastroenterology, University Hospital Regensburg, Regensburg, Germany

Correspondence to:

Niklas Verloh, email: [email protected]

Keywords: magnetic resonance imaging; liver; abdomen; fibrosis; histology

Received: November 17, 2017 Accepted: March 12, 2018 Published: April 13, 2018

ABSTRACT

Objectives: The aim of this study was to determine the diagnostic value of diffusion-weighted MRI of the liver at 3T to classify liver fibrosis/cirrhosis.

Methods: 62 patients who underwent both histopathological examination and diffusion-weighted imaging of the liver via 3T MRI within a period of 3 months were included in the study. The Ishak score (1-6) was used to determine the degree of fibrosis: No liver fibrosis (NLF; Ishak 0, n = 16), mild liver fibrosis (MLF; Ishak 1-2, n = 23), advanced liver fibrosis (ALF; Ishak 3-5, n = 12), and liver cirrhosis (LC; Ishak 6, n = 11).

Results: The corresponding ADC values for the individual patient groups were as follows: NLF: 1123 (SD 95.8); MLF: 1032 (SD 77.6); ALF: 962 (SD 68.8); LC: 1015 (SD 60.2) mm2/s. There is a significant difference between NLF and MLF (p = 0.004) and between MLF and ALF (p = 0.022). A significant difference between patients with ALF and LC (p = 0.117) could not be found.

Conclusion: Liver fibrosis/cirrhosis lowers the ADC values of the liver parenchyma in 3T MRI. However, the degree of fibrosis can only be conditionally determined on the basis of ADC values.

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Clinical Research Papers:

DWI - histology: a possible means of determining degree of liver fibrosis?

Abstract