Oncotarget

Meta-Analysis:

Long non-coding RNA CCAT1 as a diagnostic and prognostic molecular marker in various cancers: a meta-analysis

Zhihui Zhang _, Haibiao Xie, Daqiang Liang, Lanbing Huang, Feiguo Liang, Qiang Qi and Xinjian Yang

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Oncotarget. 2018; 9:23695-23703. https://doi.org/10.18632/oncotarget.24923

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Abstract

Zhihui Zhang1,2,*, Haibiao Xie2,3,*, Daqiang Liang2, Lanbing Huang1, Feiguo Liang2, Qiang Qi4 and Xinjian Yang1

1Department of Spine Surgery, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China

2Shantou University Medical College, Shantou 515041, China

3Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China

4Department of Orthopaedics, Peking University Third Hospital, Beijing 100083, China

*These authors contributed equally to this work

Correspondence to:

Xinjian Yang, email: 13823362380@139.com

Qiang Qi, email: qiqiang_puth@sohu.com

Keywords: long non-coding RNA; CCAT1; overall survival; lymph node metastasis; tumor node metastasis grade

Received: June 15, 2017     Accepted: September 20, 2017     Published: May 04, 2018

ABSTRACT

Purpose: Long non-coding RNA colon cancer-associated transcript-1 (CCAT1) is newly found to be related with diagnoses and prognosis of cancer. This meta-analysis was performed to investigate the relationship between CCAT1 expression and clinical parameters, including survival condition, lymph node metastasis and tumor node metastasis grade.

Materials and Methods: The primary literatures were collected through initial search criteria from electronic databases, including PubMed, OVID Evidence-based medicine Reviews and others (up to May 12, 2017). Eligible studies were identified and selected by the inclusion and exclusion criteria. Data was extracted and computed into Hazard ratio (HR) for the assessment of overall survival, subgroup analyses were prespecified based on the digestive tract cancer or others. Analysis of different CCAT1 expression related with lymph node metastasis or tumor node metastasis grade was conducted. Risk of bias was assessed by the Newcastle-Ottawa Scale.

Results: 9 studies were included. This meta-analysis showed that high CCAT1 expression level was related to poor overall survival, the pooled HR was 2.42 (95% confidence interval, CI: 1.86-3.16; P < 0.001; fix- effects model), similarly in the cancer type subgroups: digestive tract cancer (HR, 2.42; 95% CI, 1.79–3.29; P < 0.001; fix- effects model) and others (HR, 2.42; 95% CI, 1.42–4.13; P = 0.001; fix- effects model). The analysis showed that high CCAT1 was strongly related to positive lymph node metastasis (Odds ratio, OR: 3.24; 95% CI, 2.04-5.16; P < 0.001; fix- effects model), high tumor node metastasis stage (OR, 3.87; 95% CI, 2.53–5.92; P < 0.001; fix- effects model).

Conclusions: In conclusion, this meta-analysis revealed that CCAT1 had potential as a diagnostic and prognostic biomarker in various cancers.


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