Coffee consumption is not associated with ovarian cancer risk: a dose-response meta-analysis of prospective cohort studies
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Massimiliano Berretta1, Agnieszka Micek2, Alessandra Lafranconi3, Sabrina Rossetti4, Raffaele Di Francia5, Paolo De Paoli6, Paola Rossi7 and Gaetano Facchini4
1Department of Medical Oncology, National Cancer Institute-IRCCS, Aviano, Italy
2Department of Epidemiology and Population Studies, Jagiellonian University Medical College, Krakow, Poland
3The Research Centre on Public Health, University Milano-Bicocca, Milan, Italy
4Departmental Unit of Experimental Uro-Andrological Clinical Oncology, Department of Uro-Gynecological Oncology, Istituto Nazionale Tumori Fondazione G. Pascale-IRCCS, Naples, Italy
5Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute, Fondazione G. Pascale IRCCS, Naples, Italy
6Scientific Directorate, National Cancer Institute, Aviano, Italy
7Department of Biology and Biotechnology, L. Spallanzani University of Pavia, Pavia, Italy
Massimiliano Berretta, email: [email protected]
Keywords: coffee; ovarian cancer; postmenopausal; meta-analysis; cohort studies
Received: February 07, 2018 Accepted: February 27, 2018 Published: April 17, 2018
Background: Coffee consumption has been associated with numerous cancers, but evidence on ovarian cancer risk is controversial. Therefore, we performed a meta-analysis on prospective cohort studies in order to review the evidence on coffee consumption and risk of ovarian cancer.
Methods: Studies were identified through searching the PubMed and MEDLINE databases up to March 2017. Risk estimates were retrieved from the studies, and dose-response analysis was modelled by using restricted cubic splines. Additionally, a stratified analysis by menopausal status was performed.
Results: A total of 8 studies were eligible for the dose-response meta-analysis. Studies included in the analysis comprised 787,076 participants and 3,541 ovarian cancer cases. The results showed that coffee intake was not associated with ovarian cancer risk (RR = 1.06, 95% CI: 0.89, 1.26). Stratified and subgroup analysis showed consisted results.
Conclusions: This comprehensive meta-analysis did not find evidence of an association between the consumption of coffee and risk of ovarian cancer.
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