Oncotarget

Research Papers:

Clinical outcomes of women with ovarian metastases of colorectal cancer treated with oophorectomy with respect to their somatic mutation profiles

Yoshiko Mori _, Akihiro Nyuya, Kazuya Yasui, Toshiaki Toshima, Takashi Kawai, Fumitaka Taniguchi, Keisuke Kimura, Ryo Inada, Masahiko Nishizaki, Junko Haraga, Keiichiro Nakamura, Yuzo Umeda, Hiroyuki Kishimoto, Toshiyoshi Fujiwara, Yosuke Katata, Yoshiyuki Yamaguchi and Takeshi Nagasaka

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Oncotarget. 2018; 9:16477-16488. https://doi.org/10.18632/oncotarget.24735

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Abstract

Yoshiko Mori1,2, Akihiro Nyuya3, Kazuya Yasui1, Toshiaki Toshima1, Takashi Kawai1, Fumitaka Taniguchi1, Keisuke Kimura1, Ryo Inada1, Masahiko Nishizaki1, Junko Haraga4, Keiichiro Nakamura4, Yuzo Umeda1, Hiroyuki Kishimoto1, Toshiyoshi Fujiwara1, Yosuke Katata3, Yoshiyuki Yamaguchi3 and Takeshi Nagasaka3

1Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

2Clinical Genomic Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

3Department of Clinical Oncology, Kawasaki Medical School, Kurashiki City, Japan

4Obstetrics and Gynecology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

Correspondence to:

Takeshi Nagasaka, email: takeshin@med.kawasaki-m.ac.jp

Keywords: ovarian metastases; colorectal cancer; ovarian metastatectomy; BRAF; RAS

Received: August 15, 2017     Accepted: February 21, 2018     Published: March 27, 2018

ABSTRACT

We clarified the clinical prevalence of ovarian metastases from colorectal cancers (CRCs) in 296 female patients with CRC and evaluated clinical outcomes with relation to their mutational profiles, such as BRAF/KRAS mutation and microsatellite instability (MSI) status. The female CRCs were categorised into three subsets: CRCs with ovarian metastases [6.4% (n = 19), 5-year overall survival (OS) = 24.7%], CRCs with extra-ovarian metastases only [32.4% (n = 96), 5-year OS = 34.5%] and CRCs without any recurrence or metastasis [61.2% (n = 181), 5-year OS = 91.3%]. All patients with ovarian metastases underwent oophorectomy; of these, 9 who received preoperative chemotherapy had measurable metastases to extra-ovarian sites and the ovaries. Although 5 of 9 (56%) achieved partial response or complete response at extra-ovarian sites, no patient archived objective response at ovarian sites. Regarding the mutation profiles, in CRCs with extra-ovarian metastases only, the median survival time (MST) after initial treatments to progression to stage IV or recurrence was 13 [95% confidence interval (CI): 7–16 months] in BRAF-mutant and 34 months (95% CI: 22–58 months) in BRAF wild-type (P = 0.0033). Although ovarian metastases demonstrated poor response to systemic chemotherapy in CRCs with ovarian metastases, the MST after initial treatments to progression to stage IV or recurrence was 22 (95% CI: 21–25 months) in BRAF-mutant and 38 months (95% CI: 24–42 months) in BRAF wild-type (P = 0.0398). The outcomes of patients with ovarian metastases could be improved by oophorectomy regardless of their mutation profiles.


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