Roles of GLUT-1 and HK-II expression in the biological behavior of head and neck cancer

Hang Yang, Jiang-Tao Zhong, Shui-Hong Zhou and He-Ming Han

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Oncotarget. 2019; 10:3066-3083. https://doi.org/10.18632/oncotarget.24684

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Hang Yang1,2, Jiang-Tao Zhong1, Shui-Hong Zhou1 and He-Ming Han1

1 Department of Otorhinolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China

2 Present Address: Department of Otorhinolaryngology, The People’s Hospital of Jiangshan City, Jiangshan, Zhejiang, 324100, China

Correspondence to:

Shui-Hong Zhou,email: [email protected]

Keywords: glucose transporter-1; hexokinase II; Warburg effect; head and neck cancer

Received: April 21, 2017     Accepted: February 28, 2019     Published: April 30, 2019


The Warburg effect plays an important role in the proliferation and invasion of malignant tumors. Glucose transporter 1 and hexokinase II are two key energy transporters involved in mediating the Warburg effect. This review will analyze the mechanisms of these two markers in their effects on the biological behavior of head and neck cancer.

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