Inhibition of STAT5: A therapeutic option in BCR-ABL1-driven leukemia
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Angelika Berger1, Veronika Sexl1, Peter Valent2, Richard Moriggl3
1Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria
2 Department of Medicine I, Division of Hematology and Ludwig-Boltzmann Cluster Oncology, Medical University of Vienna, Austria
3Ludwig-Boltzmann Institute for Cancer Research, University of Veterinary Medicine, Medical University Vienna, Austria
Angelika Berger, e-mail: [email protected]
Keywords: STAT5, BCR-ABL1, tyrosine kinase, leukemia, inhibitors, SH2 domain, GTPases, nuclear translocation
Received: July 25, 2014 Accepted: September 06, 2014 Published: October 09, 2014
The two transcription factors STAT5A and STAT5B are central signaling molecules in leukemias driven by Abelson fusion tyrosine kinases and they fulfill all criteria of drug targets. STAT5A and STAT5B display unique nuclear shuttling mechanisms and they have a key role in resistance of leukemic cells against treatment with tyrosine kinase inhibitors (TKI). Moreover, STAT5A and STAT5B promote survival of leukemic stem cells. We here discuss the possibility of targeting up-stream kinases with TKI, direct STAT5 inhibition via SH2 domain obstruction and blocking nuclear translocation of STAT5. All discussed options will result in a stop of STAT5 transport to the nucleus to block STAT5-mediated transcriptional activity. In summary, recently described shuttling functions of STAT5 are discussed as potentially druggable pathways in leukemias.
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