Research Papers: Immunology:

Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus

Bi-Wen Cheng, Fu-Sung Lo, An-Mei Wang, Chen-Mei Hung, Chi-Yu Huang, Wei-Hsin Ting, Mei-Ore Yang, Chao-Hsu Lin, Chia-Ching Chen, Chiung-Ling Lin, Yi-Lei Wu and Yann-Jinn Lee _

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Oncotarget. 2018; 9:16275-16283. https://doi.org/10.18632/oncotarget.24527

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Bi-Wen Cheng1,8,*, Fu-Sung Lo2,3,*, An-Mei Wang4,6, Chen-Mei Hung5, Chi-Yu Huang1,6, Wei-Hsin Ting1,6, Mei-Ore Yang7, Chao-Hsu Lin8, Chia-Ching Chen9, Chiung-Ling Lin10, Yi-Lei Wu11 and Yann-Jinn Lee1,10,12,13,14

1Department of Pediatric Endocrinology, MacKay Children's Hospital, Taipei, Taiwan

2Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan

3College of Medicine, Chang Gung University, Taoyuan, Taiwan

4Department of Nuclear Medicine, MacKay Memorial Hospital, Taipei, Taiwan

5Department of Pediatrics, Hsinchu Cathay General Hospital, HsinChu, Taiwan

6MacKay Medicine, Nursing and Management College, New Taipei City, Taiwan

7Department of Laboratory Medicine, MacKay Memorial Hospital, Taipei, Taiwan

8Department of Pediatrics, MacKay Memorial Hospital HsinChu Branch, HsinChu, Taiwan

9Department of Pediatrics, Chiayi Christian Hospital, Chiayi, Taiwan

10Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan

11Department of Pediatric Endocrinology and Metabolism, Chuanghua Christian Children’s Hospital, Chuanghua, Taiwan

12Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan

13Department of Medicine, Mackay Medical College, New Taipei City, Taiwan

14Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

*These authors contributed equally to this work

Correspondence to:

Yann-Jinn Lee, email: [email protected]

Keywords: autoantibodies; glutamic acid decarboxylase 65 (GAD) autoantibody; insulinoma-associated protein 2 autoantibody; insulin autoantibody; type 1 diabetes mellitus; Immunology

Received: December 12, 2016     Accepted: February 13, 2018     Epub: February 19, 2018     Published: March 27, 2018


We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 autoantibody (IA2A), and insulin autoantibody (IAA) in 750 children with type 1 diabetes (T1D) living in Taiwan. GADA, IA2A, and IAA were measured by radioimmunoassay. The data were assessed by χ2 test, binary logistic regression, and Spearman rank correlation. Of the 750 T1D patients, 66.3% had GADA, 65.3% IA2A, 35.7% IAA, and 17.2% no autoantibodies. The prevalence of GADA and IA2A significantly decreased along T1D duration. The positivity of either GADA or IA2A was 89.4% within the first year of disease and decreased to 36.7% after 9 years (P = 1.22 × 10–20). Female patients had significantly higher prevalence of GADA compared with male patients (72.3% vs. 59.7%, P = 0.00027). The patients diagnosed before 12 years of age had a positive rate of 92.2% for either GADA or IA2A. Patients diagnosed at age 12 or above had a significantly lower positive rate of 81.6% (P = 0.011). GADA and IA2A significantly correlated with each other (rs = 0.245, P = 1.09 × 10–11). We concluded that autoantibodies were detectable in 89.4% of T1D patients within one year after diagnosis. Their prevalence declined with disease duration. GADA was more prevalent in female patients. GADA and IA2A weakly correlated with each other.

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