Oncotarget

Meta-Analysis:

Trigger pSA predicting recurrence from positive choline PET/CT with prostate cancer after initial treatment

Junbao Wei _, Hengzong Zhu and Xiaoli Liao

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Oncotarget. 2018; 9:14630-14641. https://doi.org/10.18632/oncotarget.24318

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Abstract

Junbao Wei1,*, Hengzong Zhu2,* and Xiaoli Liao3

1Department of Therapeutic Radiology, Guangxi Autonomous Regional Cancer Hospital & Cancer Hospital of Guangxi Medical University, Nanning, 530021, China

2Department of General Medicine, Longan Hospital of Traditional Chinese Medicine, Nanning, 532700, China

3The Oncology Department, Guangxi Autonomous Regional Cancer Hospital & Cancer Hospital of Guangxi Medical University, Nanning, 530021, China

*These authors contributed equally to this work

Correspondence to:

Xiaoli Liao, email: [email protected]

Keywords: prostate cancer; recurrence; choline PET/CT; PSA; meta-analysis

Received: July 27, 2017     Accepted: December 13, 2017     Epub: January 24, 2018     Published: March 06, 2018

ABSTRACT

Purpose: To assess the relationship between the diagnostic accuracy of Choline positron emission tomography/computed tomography (PET/CT) and the trigger prostate-specific antigen (PSA) level in patients with a biochemical recurrence of prostate cancer.

Materials and Methods: A meta-analysis was conducted to synthesize data across multiple studies.

Results: The pooled sensitivity and specificity of choline PET/CT were 82% (95% Confidence Interval (CI):80–84%) and 92% (95%CI: 90–93%), respectively. The pooled sensitivity and specificity of 18F-choline PET/CT were 81% (95%CI: 78–84%) and 90% (95%CI: 85–93%), respectively. The pooled sensitivity and specificity of 11C-choline PET/CT were 83% (95% CI: 80–86%) and 92% (95% CI: 90–94%), respectively. The pooled detection rate of 18F-choline PET/CT and 11C-choline PET/CT were 58% (95% CI: 48–68%) and 58% (95%CI: 49–68%), respectively.

Conclusions: Trigger PSA is an important risk factor for positive findings of Choline PET/CT and the detection rate of Choline PET/CT for recurrent prostate cancer increased in parallel with raises in PSA-values. Choline PET/CT got higher detection rate while the trigger PSA > 2ng/ml.


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