Polymorphisms in four microRNAs and risk of oral squamous cell cancer: a meta-analysis

Junfeng Zeng _, Xiaowei Yi, Hao Liu, Yi Yang, Yuchen Duan and Hua Chen

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Oncotarget. 2018; 9:8695-8705. https://doi.org/10.18632/oncotarget.24211

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Junfeng Zeng1,*, Xiaowei Yi2,*, Hao Liu1, Yi Yang1, Yuchen Duan1 and Hua Chen1

1Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China

2State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu,610041, China

*These authors contributed equally to this work

Correspondence to:

Hao Liu, email: [email protected]

Keywords: microRNAs; polymorphism; oral squamous cell cancer (OSCC); cancer biomarkers; meta-analysis

Received: August 23, 2017     Accepted: December 05, 2017     Published: January 12, 2018


Objectives: Single nucleotide polymorphisms in microRNAs (microRNA-196a2 rs11614913, microRNA-146a rs2910164, microRNA-149 rs2292832 and microRNA-499 rs3746444) have been inconsistently associated with risk for oral squamous cell cancer (OSCC). This meta-analysis aimed to assess the correlation between microRNA polymorphisms and susceptibility to OSCC.

Materials and Methods: Free words were used to search for the relevant studies without language limitations in electronic databases including PubMed, Embase, Web of Science and SCOPUS through June 15, 2017. Odds ratios (ORs) were calculated to investigate the effects of microRNA polymorphisms on oral cancer risk.

Results: Eleven studies were included. Analysis under the recessive model of microRNA-146a (CC vs GG+CG) showed significant differences (ORs = 0.874, P = 0.041). The G allele and the GG genotype of microRNA-499 were associated with OSCC risk (ORs >1, P < 0.05). MicroRNA-196a2 rs11614913 and microRNA-149 polymorphisms appeared to have no relationship with OSCC risk (P > 0.05). In the sensitivity analysis, there was a significant association between the TT genotype of microRNA-196a2 and OSCC risk (TT vs TC + CC, ORs < 1, P < 0.05).

Conclusions: There may be no significant relationship between microRNA-149 polymorphisms and OSCC risk, and the CC genotype of microRNA-146a may have protective effects against oral cancer. However, the G allele and the GG genotype of microRNA-499 may increase OSCC risk.

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