Long non-coding RNAs function as novel predictors and targets of non-small cell lung cancer: a systematic review and meta-analysis

Yanlu Xiong _, Tao Wang, Mingxing Wang, Jinbo Zhao, Xiaofei Li, Zhipei Zhang, Yongsheng Zhou, Jiabao Liu, Lintao Jia and Yong Han

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Oncotarget. 2018; 9:11377-11386. https://doi.org/10.18632/oncotarget.23994

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Yanlu Xiong1,*, Tao Wang1,*, Mingxing Wang1, Jinbo Zhao1, Xiaofei Li1, Zhipei Zhang1, Yongsheng Zhou3, Jiabao Liu3, Lintao Jia2 and Yong Han1

1Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China

2State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, China

3Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi'an, China

*These authors contributed equally to this work

Correspondence to:

Yong Han, email: [email protected]

Lintao Jia, email: [email protected]

Keywords: lncRNA; NSCLC; biomarker; prognosis; malignancy

Received: July 13, 2017     Accepted: November 14, 2017     Published: January 04, 2018


Objectives: Non-small cell lung cancer (NSCLC) is associated with high morbidity and mortality, leading the understanding the pathogenesis paramount. Recent studies suggest that long non-coding RNAs (lncRNAs) play an important role in NSCLC. We conducted a systematic review to examine the relationship between lncRNAs and NSCLC.

Materials and Methods: We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) to estimate overall survival (OS), and odds ratios (ORs) and 95% CIs to assess clinicopathological parameters. Also, pooled sensitivity and specificity values were used to measure the diagnostic value of lncRNAs for NSCLC. Finally, we summarized the molecular mechanisms underlying the activity of lncRNAs in NSCLC.

Results: We found that high expression of oncogenic lncRNAs was associated with a poor prognosis (OS: HR, 1.18; 95% CI, 1.14–1.22) and poor clinicopathological characteristics (tumor size: OR, 2.74 or 2.04; 95% CI, 1.66–4.52 or 1.09–3.79 based on the two classification criterias; lymph node metastasis: OR, 3.30; 95% Cl, 2.42–4.49), Also, high expression of tumor-suppressor lncRNAs was correlated with longer survival times (OS: HR, 0.54; 95% CI, 0.44–0.66) and improved clinical characteristics (tumor size: OR, 0.33 or 0.28; 95% CI, 0.14–0.75 or 0.18–0.45; lymph node metastasis: OR, 0.37; 95% Cl, 0.26–0.52). Furthermore, we found that lncRNAs could be used as serum biomarkers of NSCLC (sensitivity: 0.81; 95% CI, 0.72–0.87; specificity: 0.83; 95% CI, 0.73–0.90). Finally, lncRNAs regulated expression of key proteins, thereby mediating development of a malignant phenotype.

Conclusions: lncRNAs have significant clinical value in NSCLC and could function as novel predictors of disease and/or as therapeutic targets.

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