Research Papers:

Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fish Nothobranchius guentheri

Xia Wang _, Xiaoyuan Du, Yang Zhou, Su Wang, Feng Su and Shicui Zhang

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Oncotarget. 2018; 9:14882-14894. https://doi.org/10.18632/oncotarget.23957

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Xia Wang1, Xiaoyuan Du1, Yang Zhou3, Su Wang1, Feng Su3 and Shicui Zhang1,2

1Institute of Evolution and Marine Biodiversity and Department of Marine Biology, Ocean University of China, Qingdao 266003, China

2Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China

3Institute of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Correspondence to:

Feng Su, email: [email protected]

Shicui Zhang, email: [email protected]

Keywords: salidroside; aging; lifespan; antioxidant system; Nothobranchius

Received: February 09, 2017     Accepted: November 20, 2017     Epub: January 04, 2018     Published: March 13, 2018


One of the most studied and widely accepted conjectures of aging process is the oxidative stress theory. Previous studies have shown that salidroside can protect D-galactose-induced mouse model against aging and a formulation of Rhodiola rosea extracts (SHR-5) containing salidroside increases lifespan of fruit fly. However, direct evidence linking salidroside itself with the observed anti-aging effect in vivo and relevant molecular mechanisms are poorly defined. In this study, we first demonstrated that salidroside exhibited a time-dependent effect, and late-onset long-term salidroside dietary intake extended the lifespan in the annual fish Nothobranchius guentheri. We then showed that salidroside reduced the accumulation of lipofuscin in the gills as well as the levels of protein oxidation, lipid peroxidation and reactive oxygen species in the muscles; enhanced the activities of catalase, glutathione peroxidase, and superoxide dismutase in the fish; and decelerated the increase of P66shc, a critical factor for regulation of intracellular reactive oxygen species contents. Collectively, these data indicate that salidroside can prolong the lifespan and retard the onset of age-related biomarkers via the antioxidant system in aging fish. It also suggests that salidroside may have a potential usefulness in prolonging the lifespan of the elderly.

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