Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis

Guandi Wu _, Jiayi Xian, Xi Yang, Jiaying Li, Jichen Liu, Wenhui Dong, Shuwen Su, Jun Li, Yan Tu, Jian Peng, Dingli Xu and Qingchun Zeng

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Oncotarget. 2018; 9:8665-8674. https://doi.org/10.18632/oncotarget.23938

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Guandi Wu1, Jiayi Xian1, Xi Yang1,2, Jiaying Li1,2, Jichen Liu1, Wenhui Dong1, Shuwen Su1, Jun Li1, Yan Tu1, Jian Peng1, Dingli Xu1,2 and Qingchun Zeng1,2

1Department of Cardiology, First Clinical Medical College, Nanfang Hospital, Southern Medical University, Guangzhou, China

2Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China

Correspondence to:

Qingchun Zeng, email: [email protected]

Dingli Xu, email: [email protected]

Keywords: homocysteine; homocys; calcific aortic valve disease; aortic valve stenosis; meta-analysis

Received: June 01, 2017     Accepted: November 08, 2017     Published: January 03, 2018


Previous studies have reported inconsistent results regarding the association between homocysteine (Hcy) levels and calcific aortic valve disease (CAVD). We investigate the association between Hcy levels in patients with CAVD and controls by conducting a systematic review and meta-analysis. We conducted a systematic search of studies published prior to the end of March 2017 in the PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and the Chinese Biomedical Literature databases. Eligible studies evaluating plasma Hcy levels in CAVD patients and controls were identified by two independent investigators. Standardized mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were estimated using the random-effects model. Ten studies involving 6349 participants were included. Pooled analysis demonstrated that Hcy levels were significantly elevated in patients with CAVD compared with controls (pooled SMD: 0.57, 95% CI: 0.36–0.79). This elevation was more obvious in American and Asian populations than in Turkish populations. Furthermore, Hcy levels were significantly elevated in patients with mild-to-moderate CAVD and severe CAVD. Our results demonstrate that CAVD is associated with elevated Hcy levels.

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