The miR-17-92 cluster/QKI2/β-catenin axis promotes osteosarcoma progression
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Hongbo Yang1, Zhibin Peng1, Min Liang1, Yubo Zhang1, Yangyang Wang1, Tianwen Huang1, Yudong Jiang1, Bo Jiang1 and Yansong Wang1
1Department of Orthopaedic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
Yansong Wang, email: email@example.com
Keywords: osteosarcoma; miR-17-92 cluster; QKI2; β-catenin; progression
Received: August 01, 2017 Accepted: October 30, 2017 Epub: January 05, 2018 Published: May 18, 2018
Quaking(QKI) is an RNA binding protein, and it has been shown to serve as a tumor suppressor. However, the expression and functions of QKI in osteosarcoma progression remain poorly understood. In this study, we aimed to explore the expression of QKI2 in osteosarcoma tissues and to determine the mechanisms underlying aberrant QKI2 expression and the effect of QKI2 on osteosarcoma progression. We found that QKI2 was significantly down-regulated in osteosarcoma tissues compared with adjacent normal bone tissues. Using a series of molecular biological techniques, we demonstrated that all members of the miR-17-92 cluster were up-regulated and contributed to the down-regulation of QKI2 expression in osteosarcoma. Functional examination showed that QKI2 inhibited the proliferation, migration and invasion of osteosarcoma cells via decreasing the expression of β-catenin. Conclusively, we revealed that the regulatory axis consisting of the miR-17-92 cluster/QKI2/β-catenin plays a crucial role in the development and progression of osteosarcoma.
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