Research Papers:

Intrahepatic cholangiocarcinoma in the setting of HBV-related cirrhosis: Differentiation with hepatocellular carcinoma by using Intravoxel incoherent motion diffusion-weighted MR imaging

Yi Wei _, Feifei Gao, Dandan Zheng, Zixing Huang, Min Wang, Fubi Hu, Chenyang Chen, Ting Duan, Jie Chen, Likun Cao and Bin Song

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Oncotarget. 2018; 9:7975-7983. https://doi.org/10.18632/oncotarget.23807

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Yi Wei1,*, Feifei Gao2,*, Dandan Zheng3, Zixing Huang1, Min Wang1, Fubi Hu1, Chenyang Chen1, Ting Duan1, Jie Chen1, Likun Cao1 and Bin Song1

1Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

2Department of Radiology, Henan Provincial People’s Hospital, Zhengzhou, China

3GE Healthcare China, Beijing, China

*These authors contributed equally to this work

Correspondence to:

Bin Song, email: [email protected]

Keywords: intravoxel incoherent motion; diffusion weighted imaging; hepatocellular carcinoma; intrahepatic cholangiocarcinoma

Received: October 05, 2017     Accepted: November 13, 2017     Published: December 26, 2017


Accurate preoperative differentiation of intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) in the setting of cirrhotic liver is of great clinical significance because the treatment and prognosis of these entities differ markedly. Through a retrospectively research, we sought to determine the diagnostic performances of intravoxel incoherent motion (IVIM) and diffusion weighted imaging (DWI) parameters in the differentiating of ICC and HCC. According to the results, we found that apparent diffusion coefficient (ADC) derived from mono-exponential model and true ADC (ADCslow) derived from bi-exponential model can be used to distinguish the ICC and HCC, and ADCslowentailed the higher diagnostic performance than ADC. However, pseudo-ADC (ADCfast) and perfusion fraction (f) can not be used to differentiate ICC and HCC. These results suggested that IVIM and DWI parameters can be useful in differentiating ICC and HCC and might be helpful in selecting the treatment plan and predicting prognosis.

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