C-Kit receptor and tryptase expressing mast cells correlate with angiogenesis in breast cancer patients
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Ilaria Marech1, Michele Ammendola2, Christian Leporini3, Rosa Patruno4, Maria Luposella5, Nicola Zizzo4, Giuseppe Passantino4, Rosario Sacco2, Ammad Ahmad Farooqi6, Valeria Zuccalà7, Silvana Leo8, Rosalba Dentamaro9, Mariangela Porcelli1, Pietro Gadaleta1, Giovambattista De Sarro3, Cosmo Damiano Gadaleta1 and Girolamo Ranieri1
1Interventional and Medical Oncology Unit, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, 70124 Bari, Italy
2Department of Medical and Surgery Science Medical School, Clinical Surgery Unit, Magna Graecia University, 88100 Catanzaro, Italy
3Department of Health Science, Clinical Pharmacology and Pharmacovigilance Unit, Pharmacovigilance’s Centre Calabria Region, Magna Graecia University, Germaneto, 88100 Catanzaro, Italy
4Chair of Pathology, Veterinary Medical School, Aldo Moro University, 70010 Valenzano, Italy
5Cardiovascular Disease Unit, San Giovanni di Dio Hospital, 88900 Crotone, Italy
6Laboratory for Translational and Personalized Medicine, Rashid Latif Medical College, University of Lahore, 44000 Islamabad, Pakistan
7Pathology Unit, Pugliese-Ciaccio Hospital, 88100 Catanzaro, Italy
8Medical Oncology Unit, Vito Fazzi Hospital, Piazzetta Muratore, 73100 Lecce, Italy
9Senology Unit, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, 70124 Bari, Italy
Girolamo Ranieri, email: [email protected]
Keywords: C-Kit receptor; tryptase; mast cells; angiogenesis; breast cancer
Received: March 21, 2017 Accepted: October 28, 2017 Published: December 22, 2017
C-Kit protein is a transmembrane tyrosine kinase (TK) receptor (c-KitR-TK), which is predominantly expressed on mast cells (MCs) playing a role in tumor angiogenesis. It could be also expressed on epithelial breast cancer cells (EBCCs), but no data have been published regarding the correlation between mast cells positive to c-KitR (MCs-c-KitR), EBCCs positive to c-KitR (EBCCs-c-KitR), BC angiogenesis in terms of microvessel density (MVD) and the main clinic-pathological features. This study aims to evaluate the above parameters and their correlations in a series of selected 121 female early BC patients. It has been found a strong correlation between MVD and MCDPT, and MCs-c-KitR, MVD and MCs density positive to tryptase (MCDPT), and MCs-c-KitR and MCDPT by Pearson correlation. These data suggest an involvement of both MCDPT and MCs-c-KitR in BC tumor angiogenesis. Furthermore, BC tissue expressing c-KitR could be a putative predictive factor to c-KitR-TK inhibitors. In this way, selected patients with higher MCs-c-KitR could be candidate to receive c-KitR-TK inhibitors (e.g. masitinib, sunitinib) or tryptase inhibitors (e.g. nafamostat mesilate, gabexate mesilate).
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