Research Papers: Gerotarget (Focus on Aging):

Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men

Yuji Shimizu _, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Shin-Ya Kawashiri and Takahiro Maeda

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Oncotarget. 2018; 9:7749-7757. https://doi.org/10.18632/oncotarget.23660

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Yuji Shimizu1,2, Shimpei Sato1, Jun Koyamatsu3, Hirotomo Yamanashi3, Mako Nagayoshi1, Koichiro Kadota1, Shin-Ya Kawashiri1 and Takahiro Maeda1,3

1Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan

2Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan

3Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan

Correspondence to:

Yuji Shimizu, email: [email protected]

Keywords: platelets; height; vascular remodeling; CIMT; CD34-positive cell; Gerotarget

Received: September 29, 2017     Accepted: October 30, 2017     Published: December 23, 2017


Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a cross-sectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.

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