Association between red and processed meat intake and colorectal adenoma incidence and recurrence: a systematic review and meta-analysis

Zhanwei Zhao, Zifang Yin, Zhenning Hang, Chaojun Zhang _ and Qingchuan Zhao

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Oncotarget. 2018; 9:32373-32382. https://doi.org/10.18632/oncotarget.23561

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Zhanwei Zhao1,2, Zifang Yin3, Zhenning Hang2, Chaojun Zhang1 and Qingchuan Zhao2

1Department of Surgery, Navy General Hospital of PLA, Beijing, China

2Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China

3Department of Obstetrics, Northwestern Women and Children’s Hospital, Shaanxi Province, China

Correspondence to:

Chaojun Zhang, email: [email protected]

Qingchuan Zhao, email: [email protected]

Keywords: meta-analysis; red meat; processed meat; colorectal adenoma; recurrence

Received: February 06, 2017     Accepted: October 28, 2017     Epub: December 21, 2017     Published: August 17, 2017


The associations between red and processed meat intake and colorectal adenoma (CRA) incidence and recurrence are inconclusive. We performed a systematic review and meta-analysis to analysis these associations. We conducted a systematic search of PubMed, EMBASE and Web of Science up to December 2016. The relative risks (RRs) and 95% confidence intervals (CIs) were assessed. Subgroup analyses, dose-response-analyses, subtype analyses and analyses of CRA locations were also conducted. Twenty-seven studies that involved 208,117 participants and 19,150 cases met criteria. The RRs of the highest versus lowest intakes for CRA incidence were 1.23 (1.15–1.31) for red meat and 1.15 (1.07–1.24) for processed meat. Dose-response analyses for meat per 100 g/day yielded the results were consistent with the original analyses, with 1.14 (1.07–1.20) for red meat and 1.27 (1.03–1.50) for processed meat. Additionally, there were no associations between red and processed meat intake and CRA recurrence, including total CRA (P > 0.05), advanced CRA (P > 0.05) and multiple CRA (P > 0.05). In conclusion, our findings support the hypothesis that red and processed meat intake was associated with an increased CRA incidence but not for CRA recurrence.

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