Association between red and processed meat intake and colorectal adenoma incidence and recurrence: a systematic review and meta-analysis
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Zhanwei Zhao1,2, Zifang Yin3, Zhenning Hang2, Chaojun Zhang1 and Qingchuan Zhao2
1Department of Surgery, Navy General Hospital of PLA, Beijing, China
2Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China
3Department of Obstetrics, Northwestern Women and Children’s Hospital, Shaanxi Province, China
Chaojun Zhang, email: email@example.com
Qingchuan Zhao, email: firstname.lastname@example.org
Keywords: meta-analysis; red meat; processed meat; colorectal adenoma; recurrence
Received: February 06, 2017 Accepted: October 28, 2017 Epub: December 21, 2017 Published: August 17, 2017
The associations between red and processed meat intake and colorectal adenoma (CRA) incidence and recurrence are inconclusive. We performed a systematic review and meta-analysis to analysis these associations. We conducted a systematic search of PubMed, EMBASE and Web of Science up to December 2016. The relative risks (RRs) and 95% confidence intervals (CIs) were assessed. Subgroup analyses, dose-response-analyses, subtype analyses and analyses of CRA locations were also conducted. Twenty-seven studies that involved 208,117 participants and 19,150 cases met criteria. The RRs of the highest versus lowest intakes for CRA incidence were 1.23 (1.15–1.31) for red meat and 1.15 (1.07–1.24) for processed meat. Dose-response analyses for meat per 100 g/day yielded the results were consistent with the original analyses, with 1.14 (1.07–1.20) for red meat and 1.27 (1.03–1.50) for processed meat. Additionally, there were no associations between red and processed meat intake and CRA recurrence, including total CRA (P > 0.05), advanced CRA (P > 0.05) and multiple CRA (P > 0.05). In conclusion, our findings support the hypothesis that red and processed meat intake was associated with an increased CRA incidence but not for CRA recurrence.
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