Impact of LMP7 (rs2071543) gene polymorphism in increasing cancer risk: evidence from a meta-analysis and trial sequential analysis

Raju K. Mandal, Sajad A. Dar, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K. Panda, Bhartendu N. Mishra, Naseem Akhter, Mohammed Y. Areeshi and Shafiul Haque _

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Oncotarget. 2018; 9:6572-6585. https://doi.org/10.18632/oncotarget.23547

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Raju K. Mandal1,*, Sajad A. Dar1,2,*, Arshad Jawed1, Mohd Wahid1,3, Mohtashim Lohani1, Aditya K. Panda4, Bhartendu N. Mishra5, Naseem Akhter6, Mohammed Y. Areeshi1 and Shafiul Haque1

1Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia

2The University College of Medical Sciences and GTB Hospital University of Delhi, Delhi 110095, India

3Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia A Central University, New Delhi 110025, India

4Centre for Life Sciences, Central University of Jharkhand, Ranchi, Jharkhand 835205, India

5Department of Biotechnology, Institute of Engineering and Technology, Lucknow, Uttar Pradesh 226021, India

6Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha 65431, Saudi Arabia

*These authors contributed equally to this work

Correspondence to:

Shafiul Haque, email: [email protected]

Keywords: meta-analysis; LMP7; cancer susceptibility; polymorphism; trial sequential analysis

Received: March 21, 2017     Accepted: November 01, 2017     Published: December 21, 2017


Genetic variant LMP7 (low molecular weight polypeptide 7) –145 C > A may influence the function of immune surveillance of an individual and lead to cancer development. Various studies have investigated the relevance of LMP7 –145 C > A gene polymorphism with cancer risk; but, their results are conflicting and inconsistent. To obtain a comprehensive conclusion, a meta-analysis was performed by including eight eligible published studies retrieved from PubMed (Medline), EMBASE and Google Scholar web search until December 2016. Individuals with AA genotype (AA vs CC: p = 0.001; OR = 2.602, 95% CI = 1.780 to 3.803) of LMP7 -145 C > A were found to have 2 folds higher risk of cancer than those with CC genotype. The recessive genetic model (AA vs AC + CC) also indicated that individuals with AA genotype have 2 folds higher cancer risk than AC and CC genotypes (p = 0.001; OR = 2.216, 95% CI = 1.525 to 3.221). Also, significant increased cancer risk was observed in Asians but not in Caucasians. No publication bias was observed during the analysis. Trial sequential analysis also strengthened our current findings. These results suggest that genetic variant LMP7–145 C > A has significant role in increasing cancer risk in overall and Asian population, and could be useful as a prognostic marker for early cancer predisposition.

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