Oncotarget

Reviews:

MicroRNA expression and activity in T-cell acute lymphoblastic leukemia

Fang Ye _

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Oncotarget. 2018; 9:5445-5458. https://doi.org/10.18632/oncotarget.23539

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Abstract

Fang Ye1

1Department of Hematology, Beijing Chuiyangliu Hospital Affiliated to Tsinghua University, Beijing, China

Correspondence to:

Fang Ye, email: yefang2006369@163.com

Keywords: MicroRNA; T-ALL; NOTCH1

Received: October 27, 2017     Accepted: December 01, 2017     Published: December 20, 2017

ABSTRACT

T-cell acute lymphoblastic leukemia (T-ALL) is a lymphoid malignancy caused by the oncogenic transformation of immature T-cell progenitors. Many biologically relevant genetic and epigenetic alterations have been identified as driving factors for this transformation. Recently, microRNAs (miRNAs) have been shown to influence various leukemias, including T-ALL. Aberrant expression of miRNAs can function as either oncogenes or tumor suppressors in T-ALL through the regulation of cell migration, invasion, proliferation, apoptosis, and chemoresistance. This occurs by targeting key signaling pathways or transcriptional factors that play a critical role in T-ALL pathology and progression. Different miRNA expression profiles have been linked to specific genetic subtypes of human T-ALL. Furthermore, miRNAs can also act as independent prognostic factors to predict clinical outcomes for T-ALL patients. In the current review, we will focus on the role of miRNAs in the development and progression of T-ALL.


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