MicroRNA expression and activity in T-cell acute lymphoblastic leukemia
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1Department of Hematology, Beijing Chuiyangliu Hospital Affiliated to Tsinghua University, Beijing, China
Fang Ye, email: [email protected]
Keywords: MicroRNA; T-ALL; NOTCH1
Received: October 27, 2017 Accepted: December 01, 2017 Published: December 20, 2017
T-cell acute lymphoblastic leukemia (T-ALL) is a lymphoid malignancy caused by the oncogenic transformation of immature T-cell progenitors. Many biologically relevant genetic and epigenetic alterations have been identified as driving factors for this transformation. Recently, microRNAs (miRNAs) have been shown to influence various leukemias, including T-ALL. Aberrant expression of miRNAs can function as either oncogenes or tumor suppressors in T-ALL through the regulation of cell migration, invasion, proliferation, apoptosis, and chemoresistance. This occurs by targeting key signaling pathways or transcriptional factors that play a critical role in T-ALL pathology and progression. Different miRNA expression profiles have been linked to specific genetic subtypes of human T-ALL. Furthermore, miRNAs can also act as independent prognostic factors to predict clinical outcomes for T-ALL patients. In the current review, we will focus on the role of miRNAs in the development and progression of T-ALL.
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